DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klu and klu-2

DIOPT Version :9

Sequence 1:	NP_001261690.1	Gene:	klu / 39228	FlyBaseID:	FBgn0013469	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_491843.3	Gene:	klu-2 / 172339	WormBaseID:	WBGene00022592	Length:	386	Species:	Caenorhabditis elegans

Alignment Length:	373	Identity:	102/373 - (27%)
Similarity:	150/373 - (40%)	Gaps:	100/373 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   378 PSLPSPPRSESSVTNNVATTTTSSTTKKRSSPKPKGKKGEKKPMPPPQERPL------------- 429
            |::..||..|.|...:|||.::|:.|:.|...:.....|:.: .||.:.||:
Worm     5 PTMIIPPTVEISTIIDVATPSSSADTENRGDGESSVFIGQLQ-HPPLRRRPVSAMASLPWVAYQA 68

  Fly   430 ---------DLCMRNEVEPKKYKKSGSKSSLESRSAGMMP-PPPALSAASSLE-SMSALSPASSS 483
                     ||.:.:.:........|..||:...|...:. .||.||..:..: |..:||...||
Worm    69 PREDGTDDEDLAVDSTLFLSTSPGIGFGSSMPGGSVSSLALSPPGLSPLNFNDGSPFSLSSTPSS 133

  Fly   484 HSG-----------HMPI------TSAATPNHQPPPNSPYANAMNAAHAAAAAAAAAMIKMEMPL 531
            .|.           |:|.      ::.||.:..||..||...|:|..|..:|          ..:
Worm   134 TSSLVRNQNRFTFDHIPFIGSSTNSTPATASTGPPGLSPGGAALNIEHEKSA----------FEI 188

  Fly   532 HPLHHQQ----MHHSQVPT--TTVGVPVIKGDVASPTTKETVAWRYNLDVSPVVEEMPPGSDVAY 590
            ...|||.    :...::.|  :|.....::..::..||..|.:..   ..|...:...||.
Worm   189 VSCHHQSAEEILQRVRLGTSGSTSSANNLRNSLSEATTTTTGSVE---STSGTADGSAPGQ---- 246

  Fly   591 VCPTCGQMFSLHDRLAKHMASRHKSRNPANDIAKAYSCDVCRRSFARSDMLTRHMRLHTGVKPYT 655
                                               |.|.:|.:.|.|.|:|:||.|.|||.||:.
Worm   247 -----------------------------------YYCFICEKDFRRPDILSRHTRRHTGEKPFK 276

  Fly   656 CKVCGQVFSRSDHLSTHQRTHTGEKPYKCPQCPYAACRRDMITRHMRT 703
            |:.||:.|||||||.||:||||.||||.|..|.|:|.|||::||||.|
Worm   277 CEDCGRFFSRSDHLRTHRRTHTDEKPYHCCVCNYSARRRDVLTRHMST 324

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klu	NP_001261690.1	FYDLN_acid	<182..248	CDD:302856
		C2H2 Zn finger	592..613	CDD:275368	0/20 (0%)
		COG5048	607..>687	CDD:227381	36/79 (46%)
		zf-C2H2	626..648	CDD:278523	10/21 (48%)
		C2H2 Zn finger	628..648	CDD:275368	9/19 (47%)
		zf-H2C2_2	640..665	CDD:290200	13/24 (54%)
		C2H2 Zn finger	656..676	CDD:275368	13/19 (68%)
		zf-H2C2_2	668..690	CDD:290200	14/21 (67%)
		C2H2 Zn finger	684..704	CDD:275368	12/20 (60%)
klu-2	NP_491843.3	COG5048	216..>298	CDD:227381	35/123 (28%)
		C2H2 Zn finger	249..269	CDD:275368	9/19 (47%)
		zf-H2C2_2	262..286	CDD:290200	13/23 (57%)
		COG5048	273..>328	CDD:227381	34/52 (65%)
		C2H2 Zn finger	277..297	CDD:275368	13/19 (68%)
		zf-H2C2_2	289..314	CDD:290200	16/24 (67%)
		C2H2 Zn finger	305..324	CDD:275368	11/18 (61%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160166745
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.890