DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klu and ZNF169

DIOPT Version :9

Sequence 1:	NP_001261690.1	Gene:	klu / 39228	FlyBaseID:	FBgn0013469	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_003439.2	Gene:	ZNF169 / 169841	HGNCID:	12957	Length:	604	Species:	Homo sapiens

Alignment Length:	558	Identity:	127/558 - (22%)
Similarity:	184/558 - (32%)	Gaps:	178/558 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   282 NQPMNKENPLHVDI-----KTEI-PSPYDRYFPIPSPLFGYYLH-TKYLNEVFRRRHDLYPSPLQ 339
            ::|..:||...:|:     :||. ||     ||          | ..:.:....|::.|...|.|
Human    70 DEPWREENEHLLDLCPAEPRTEFQPS-----FP----------HLVAFSSSQLLRQYALSGHPTQ 119

  Fly   340 HTPSSIA------------------SETETSPNAQERKS----SSNHVLPHA------LLANNSP 376
            ..|||.|                  .||| .|::..||.    |.....||.      :..|...
Human   120 IFPSSSAGGDFQLEAPRCSSEKGESGETE-GPDSSLRKRPSRISRTFFSPHQGDPVEWVEGNREG 183

  Fly   377 PPSLPSPPRSESSVTNNV---ATTTTSSTTKKRSSPKPKGKKG-----EKKPMPPPQERPLDLCM 433
            ...|....|.....::.:   |.|:.|....:.:......||.     :|..:.|...|  ..|.
Human   184 GTDLRLAQRMSLGGSDTMLKGADTSESGAVIRGNYRLGLSKKSSLFSHQKHHVCPECGR--GFCQ 246

  Fly   434 RNEVEPKKYKKSGSKSSLESRSAGMMPPPPALSAASSLESMSALSPASSSHSG-----------H 487
            |:::...:...:|.|            |.............::||.....|||           |
Human   247 RSDLIKHQRTHTGEK------------PYLCPECGRRFSQKASLSIHQRKHSGEKPYVCRECGRH 299

  Fly   488 MPITSAATPNHQPPPNSPYANAMNAAHAAAAAAAAAMIKMEMPLHPLHHQQMHHSQVPTTTVGVP 552
            ...||:.| ||:        ...:..............:.::.|  |.||:.|
Human   300 FRYTSSLT-NHK--------RIHSGERPFVCQECGRGFRQKIAL--LLHQRTH------------ 341

  Fly   553 VIKGDVASPTTKETVAWRYNLDVSPVVEEMPPGSDVAYVCPTCGQMFSLHDRLAKHMASRHKSRN 617
                                      :||.|      :|||.||:.|.....|.:|.:| |....
Human   342 --------------------------LEEKP------FVCPECGRGFCQKASLLQHQSS-HTGER 373

  Fly   618 P---------------------ANDIAKAYSCDVCRRSFARSDMLTRHMRLHTGVKPYTCKVCGQ 661
            |                     .:...|.|.|..|..||.:...|.||.|.|||.|||.|..||:
Human   374 PFLCLECGRSFRQQSLLLSHQVTHSGEKPYVCAECGHSFRQKVTLIRHQRTHTGEKPYLCPQCGR 438

  Fly   662 VFSRSDHLSTHQRTHTGEKPYKCPQCPYAACRRDMITRHMRTHTRYDSRGGSREGREGREGRE-G 725
            .||:...|..|||||||||||.||.|.....::..:.||.||||      |.:.....:.||. |
Human   439 GFSQKVTLIGHQRTHTGEKPYLCPDCGRGFGQKVTLIRHQRTHT------GEKPYLCPKCGRAFG 497

  Fly   726 KESRDSRRSNERIEEPNSPGSHSLLDMKMNMNMGMGMG 763
            .:|..:|...          :||..::.::...|.|:|
Human   498 FKSLLTRHQR----------THSEEELYVDRVCGQGLG 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klu	NP_001261690.1	FYDLN_acid	<182..248	CDD:302856
		C2H2 Zn finger	592..613	CDD:275368	8/20 (40%)
		COG5048	607..>687	CDD:227381	39/100 (39%)
		zf-C2H2	626..648	CDD:278523	9/21 (43%)
		C2H2 Zn finger	628..648	CDD:275368	8/19 (42%)
		zf-H2C2_2	640..665	CDD:290200	14/24 (58%)
		C2H2 Zn finger	656..676	CDD:275368	9/19 (47%)
		zf-H2C2_2	668..690	CDD:290200	15/21 (71%)
		C2H2 Zn finger	684..704	CDD:275368	6/19 (32%)
ZNF169	NP_003439.2	KRAB	14..73	CDD:214630	0/2 (0%)
		KRAB	14..53	CDD:279668
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	122..182		14/60 (23%)
		COG5048	223..>584	CDD:227381	93/389 (24%)
		zf-C2H2	235..257	CDD:278523	4/23 (17%)
		C2H2 Zn finger	237..257	CDD:275368	4/21 (19%)
		zf-H2C2_2	249..274	CDD:290200	3/36 (8%)
		C2H2 Zn finger	265..285	CDD:275368	2/19 (11%)
		zf-H2C2_2	277..302	CDD:290200	6/24 (25%)
		C2H2 Zn finger	293..313	CDD:275368	6/28 (21%)
		zf-H2C2_2	305..330	CDD:290200	3/33 (9%)
		C2H2 Zn finger	321..341	CDD:275368	4/21 (19%)
		C2H2 Zn finger	349..369	CDD:275368	8/20 (40%)
		C2H2 Zn finger	377..397	CDD:275368	0/19 (0%)
		zf-C2H2	403..425	CDD:278523	9/21 (43%)
		C2H2 Zn finger	405..425	CDD:275368	8/19 (42%)
		zf-H2C2_2	418..442	CDD:290200	14/23 (61%)
		C2H2 Zn finger	433..453	CDD:275368	9/19 (47%)
		zf-H2C2_2	449..468	CDD:290200	14/18 (78%)
		C2H2 Zn finger	461..481	CDD:275368	6/19 (32%)
		zf-H2C2_2	474..496	CDD:290200	9/27 (33%)
		C2H2 Zn finger	489..509	CDD:275368	5/29 (17%)
		C2H2 Zn finger	518..537	CDD:275368	3/8 (38%)
		C2H2 Zn finger	545..565	CDD:275368
		zf-H2C2_2	557..582	CDD:290200
		C2H2 Zn finger	573..592	CDD:275368
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	584..604
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910