DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment klu and ZNF543

DIOPT Version :9

Sequence 1:	NP_001261690.1	Gene:	klu / 39228	FlyBaseID:	FBgn0013469	Length:	818	Species:	Drosophila melanogaster
Sequence 2:	NP_998763.2	Gene:	ZNF543 / 125919	HGNCID:	25281	Length:	600	Species:	Homo sapiens

Alignment Length:	152	Identity:	53/152 - (34%)
Similarity:	78/152 - (51%)	Gaps:	12/152 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   558 VASPTTKETVAWR---YNLDV-SPVVEEMPPGSDVAYVCPTCGQMFSLHDRLAKHMASRHKSRNP 618
            |.:..|::.|:..   |..|. .||.:.:......:|.|..||::|..:..|.:|        ..
Human   163 VCTKITQKQVSTEGDLYECDSHGPVTDALIREEKNSYKCEECGKVFKKNALLVQH--------ER 219

  Fly   619 ANDIAKAYSCDVCRRSFARSDMLTRHMRLHTGVKPYTCKVCGQVFSRSDHLSTHQRTHTGEKPYK 683
            .:...|.|.|..|.::|::|..|.:|:.:|||.|||.|..||:.|:|..||:.|||.|:||||||
Human   220 IHTQVKPYECTECGKTFSKSTHLLQHLIIHTGEKPYKCMECGKAFNRRSHLTRHQRIHSGEKPYK 284

  Fly   684 CPQCPYAACRRDMITRHMRTHT 705
            |.:|..|...|.....|.|:||
Human   285 CSECGKAFTHRSTFVLHHRSHT 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
klu	NP_001261690.1	FYDLN_acid	<182..248	CDD:302856
		C2H2 Zn finger	592..613	CDD:275368	6/20 (30%)
		COG5048	607..>687	CDD:227381	33/79 (42%)
		zf-C2H2	626..648	CDD:278523	7/21 (33%)
		C2H2 Zn finger	628..648	CDD:275368	6/19 (32%)
		zf-H2C2_2	640..665	CDD:290200	12/24 (50%)
		C2H2 Zn finger	656..676	CDD:275368	10/19 (53%)
		zf-H2C2_2	668..690	CDD:290200	14/21 (67%)
		C2H2 Zn finger	684..704	CDD:275368	6/19 (32%)
ZNF543	NP_998763.2	KRAB	9..69	CDD:214630
		COG5048	<75..329	CDD:227381	53/152 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..131
		C2H2 Zn finger	201..221	CDD:275368	6/27 (22%)
		COG5048	223..562	CDD:227381	39/84 (46%)
		C2H2 Zn finger	229..249	CDD:275368	6/19 (32%)
		C2H2 Zn finger	257..277	CDD:275368	10/19 (53%)
		C2H2 Zn finger	285..305	CDD:275368	6/19 (32%)
		C2H2 Zn finger	313..333	CDD:275368
		C2H2 Zn finger	341..361	CDD:275368
		C2H2 Zn finger	369..389	CDD:275368
		C2H2 Zn finger	397..417	CDD:275368
		C2H2 Zn finger	425..445	CDD:275368
		C2H2 Zn finger	453..473	CDD:275368
		C2H2 Zn finger	481..501	CDD:275368
		C2H2 Zn finger	509..529	CDD:275368
		C2H2 Zn finger	537..557	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S12228
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.950