DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aps and NUDT11

DIOPT Version :9

Sequence 1:	NP_648421.1	Gene:	Aps / 39226	FlyBaseID:	FBgn0036111	Length:	177	Species:	Drosophila melanogaster
Sequence 2:	NP_060629.2	Gene:	NUDT11 / 55190	HGNCID:	18011	Length:	164	Species:	Homo sapiens

Alignment Length:	153	Identity:	91/153 - (59%)
Similarity:	112/153 - (73%)	Gaps:	1/153 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VKEKPNSTRIYDKDGFRRRAACICVKSENEAEVLLVTSSRRPELWIVPGGGVEPEEESSVTAVRE 66
            :|.|||.||.||.:||::||||:|.:||.|.|||||:|||.|:.|||||||:|||||....||||
Human     1 MKCKPNQTRTYDPEGFKKRAACLCFRSEREDEVLLVSSSRYPDRWIVPGGGMEPEEEPGGAAVRE 65

  Fly    67 VLEEAGVVGDLGRCLGVFE-NNDHMHRTEVFVMNVTQELDEWEDSRSIGRKRQWFTIDDALSQLA 130
            |.|||||.|.|||.||||| |.|..|||.|:|:.||:.|::||||.||||||:||.::||:..|.
Human    66 VYEEAGVKGKLGRLLGVFEQNQDRKHRTYVYVLTVTELLEDWEDSVSIGRKREWFKVEDAIKVLQ 130

  Fly   131 LHKPTQQHYLMQLQHSKTLDNTN 153
            .|||....||.:|:...:..|.|
Human   131 CHKPVHAEYLEKLKLGGSPTNGN 153

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aps	NP_648421.1	Nudix_Hydrolase_9	19..137	CDD:240024	76/118 (64%)
NUDT11	NP_060629.2	Substrate binding. /evidence=ECO:0000250\|UniProtKB:O95989	17..19		0/1 (0%)
		Nudix_Hydrolase_9	18..137	CDD:240024	76/118 (64%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:O95989	38..40		1/1 (100%)
		Nudix box	50..71		14/20 (70%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:O95989	89..91		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..164		2/10 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I4083
eggNOG	1	0.900	-	-		E1_COG0494
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3846
Isobase	1	0.950	-	0	Normalized mean entropy	S1746
OMA	1	1.010	-	-		QHG58445
OrthoDB	1	1.010	-	-		D1324716at2759
OrthoFinder	1	1.000	-	-		FOG0000621
OrthoInspector	1	1.000	-	-		otm41446
orthoMCL	1	0.900	-	-		OOG6_101097
Panther	1	1.100	-	-	O	PTHR12629
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R74
SonicParanoid	1	1.000	-	-		X795
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.820