DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aps and Nudt10

DIOPT Version :9

Sequence 1:	NP_648421.1	Gene:	Aps / 39226	FlyBaseID:	FBgn0036111	Length:	177	Species:	Drosophila melanogaster
Sequence 2:	NP_001026834.1	Gene:	Nudt10 / 102954	MGIID:	2147931	Length:	164	Species:	Mus musculus

Alignment Length:	163	Identity:	96/163 - (58%)
Similarity:	116/163 - (71%)	Gaps:	3/163 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 VKEKPNSTRIYDKDGFRRRAACICVKSENEAEVLLVTSSRRPELWIVPGGGVEPEEESSVTAVRE 66
            :|.|||.||.||.:||::||||:|.:||.|.|||||:|||.|:.|||||||:|||||....||||
Mouse     1 MKCKPNQTRTYDPEGFKKRAACLCFRSEREDEVLLVSSSRYPDRWIVPGGGMEPEEEPDGAAVRE 65

  Fly    67 VLEEAGVVGDLGRCLGVFE-NNDHMHRTEVFVMNVTQELDEWEDSRSIGRKRQWFTIDDALSQLA 130
            |.|||||.|.|||.||||| |.|..|||.|||:.||:.|::||||.||||||:||.|:||:..|.
Mouse    66 VYEEAGVKGKLGRLLGVFEQNQDRKHRTYVFVLTVTELLEDWEDSVSIGRKREWFKIEDAIKVLQ 130

  Fly   131 LHKPTQQHYLMQLQHSKTLDNTNRVVNATHPPK 163
            .|||....||.:|:...:..|.|..  |..||:
Mouse   131 CHKPVHAEYLEKLKLGGSPTNGNSA--APSPPE 161

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aps	NP_648421.1	Nudix_Hydrolase_9	19..137	CDD:240024	78/118 (66%)
Nudt10	NP_001026834.1	Substrate binding. /evidence=ECO:0000250\|UniProtKB:O95989	17..19		0/1 (0%)
		Nudix_Hydrolase_9	18..137	CDD:240024	78/118 (66%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:O95989	38..40		1/1 (100%)
		Nudix box	50..71		14/20 (70%)
		Substrate binding. /evidence=ECO:0000250\|UniProtKB:O95989	89..91		0/1 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..164		5/20 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	159	1.000	Domainoid score	I4070
eggNOG	1	0.900	-	-		E1_COG0494
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	193	1.000	Inparanoid score	I3835
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG58445
OrthoDB	1	1.010	-	-		D1324716at2759
OrthoFinder	1	1.000	-	-		FOG0000621
OrthoInspector	1	1.000	-	-		otm43498
orthoMCL	1	0.900	-	-		OOG6_101097
Panther	1	1.100	-	-	O	PTHR12629
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R74
SonicParanoid	1	1.000	-	-		X795
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.870