DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG6418 and Dbp73D

DIOPT Version :9

Sequence 1:	NP_648413.1	Gene:	CG6418 / 39218	FlyBaseID:	FBgn0036104	Length:	791	Species:	Drosophila melanogaster
Sequence 2:	NP_476833.1	Gene:	Dbp73D / 39871	FlyBaseID:	FBgn0004556	Length:	687	Species:	Drosophila melanogaster

Alignment Length:	614	Identity:	152/614 - (24%)
Similarity:	251/614 - (40%)	Gaps:	166/614 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 DDDDEPREKEIEQAYIPAPGSPGAPPTSAKKQEDSDSDEDP-LEQFMAGINQQVEKEKRQQAPKP 157
            :::||..:|.:::|           ....:|.|..:..|.| ||:..:.:.:...||::.:.|:.
  Fly    24 NNEDEILQKLLKKA-----------AKRKRKHEAIEVVETPILEKETSDVKESESKEEQVEEPEK 77

  Fly   158 PTQAVRGDIDDEDDEESYYRYMKENPNAGLRDEGSDQEIEYDE-----DGNPIAP----PKKKDI 213
            |.:.|:    :||...:.::.:..:.:|..:.:...|...:..     :|..:.|    |..:.|
  Fly    78 PLEVVQ----EEDVPSNEFQVLGGDDSAAKKKKVQMQLPNWLAHPTIIEGGSLQPEEEVPASEAI 138

  Fly   214 DPLPPIYHSEIEYEPFEKNFYTQHDDIAALDDEQVRELRRTLGVKVTGPSPPKPVTSFGHFGFDE 278
            |        :::|  .||  ||    ..||...:::.|                      |...:
  Fly   139 D--------QLDY--LEK--YT----CQALKQMKIKRL----------------------FPVQK 165

  Fly   279 QLIKAVRKAEYTQPTPIQAQAVPTALSGRDIIGIAKTGSGKTAAFIWPMLMHVMDQKQLKPGDGP 343
            |:|          |..::|.|.|.....|||...|.||||||.||..|::..:..:...|..
  Fly   166 QVI----------PWILEAHAKPPPFRPRDICVSAPTGSGKTLAFAIPIVQLLSQRVDCKVR--- 217

  Fly   344 IGLILAPTRELSLQIYNEAKKFGKVYNLNVVCCYGGGSKW--EQSKALEQ-------GAEIIVAT 399
             .|::.|..||:||:|....:......|. ||......|.  ||.|.:||       .|:|:|.|
  Fly   218 -ALVVLPVAELALQVYRVISELCSKTELE-VCLLSKQHKLEDEQEKLVEQYKGKYYSKADIVVTT 280

  Fly   400 PGRMIDMVKMKATN---LRRVTFLVLDEADRMFHMGFEPQVRSICNHVRPDRQ----------C- 450
            |||::|  .:.||.   |:.:.|||:|||||:....|:..:..:.:||:....          |
  Fly   281 PGRLVD--HLHATKGFCLKSLKFLVIDEADRIMDAVFQNWLYHLDSHVKETTDQLLAGTQAPLCY 343

  Fly   451 -------------LMFSATFKKRIE----------RLARDVLSDPV---RIVQGDLNEANQDITQ 489
                         |:||||..:..|          ||...||:.||   ...:|...||..|..|
  Fly   344 AELQASFGKQPHKLLFSATLSQDPEKLQDLRLFQPRLFATVLTMPVLKDATEEGADTEALTDPGQ 408

  Fly   490 SVYVFPNPLQ------------------------KWNWLLCHLVKFLSEGSVLIFVTKKVDAETV 530
            .|..:..|.:                        ||...|| ......:.:.|.||.|
  Fly   409 FVGRYTTPAELTEQYCVTELRLKPLTVFALVEKYKWKRFLC-FTNSSDQATRLTFVLK------- 465

  Fly   531 SNNLLIKEYNCLL--LHGDMDQADRNKVITQFKRKECDILVATDVAARGLDIPHIRNVVNYDTAR 593
               :|.::|:..:  |.|::....||:.:..|...:.:.|:.:|..|||:|:..:..|::|:|.|
  Fly   466 ---VLFQKYSTKVSELSGNLSAKVRNERLRDFAAGKINGLICSDALARGIDVADVDVVLSYETPR 527

  Fly   594 DIETHTHRIGRTGRAGEKGNAYTLVTDKD 622
            .|.|:.||:|||.|||.||.|.|::|::|
  Fly   528 HITTYIHRVGRTARAGRKGTAVTVLTEQD 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG6418	NP_648413.1	DEADc	271..475	CDD:238167	72/252 (29%)
		DEXDc	284..489	CDD:214692	73/253 (29%)
		Helicase_C	504..609	CDD:278689	31/106 (29%)
Dbp73D	NP_476833.1	PRK11192	149..629	CDD:236877	123/458 (27%)
		DEAD	162..370	CDD:278688	65/224 (29%)
		HELICc	418..551	CDD:238034	38/143 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45451733
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24031
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	2.030