DRSC/TRiP Functional Genomics Resources

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Protein Alignment tna and PIAS2

DIOPT Version :10

Sequence 1:NP_001368945.1 Gene:tna / 39217 FlyBaseID:FBgn0026160 Length:1186 Species:Drosophila melanogaster
Sequence 2:NP_001340963.1 Gene:PIAS2 / 9063 HGNCID:17311 Length:622 Species:Homo sapiens


Alignment Length:608 Identity:132/608 - (21%)
Similarity:221/608 - (36%) Gaps:158/608 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   547 GGMCPAGPGAVATTGNPYQNQGFQQNYQHSPVPGNPTPPLTPACSVPYV------------SPNP 599
            ||..|..|. :|..|            .|| :|.....|.:|:..|..|            .|:|
Human    87 GGSSPVEPD-LAVAG------------IHS-LPSTSVTPHSPSSPVGSVLLQDTKPTFEMQQPSP 137

  Fly   600 DIKPPMDNSEEMRLTFPVRD--GIILAPFRLLHNLSVSN-----HVFHL-KQNVYNTLMCRNDL- 655
            .| ||:....::: ..|..|  .:::.|..|:.: |:..     .:|.| .|.|....:.|:.| 
Human   138 PI-PPVHPDVQLK-NLPFYDVLDVLIKPTSLVQS-SIQRFQEKFFIFALTPQQVREICISRDFLP 199

  Fly   656 --------ELQLK-CFHQDDRQMNTNWPHTVTVSAN----------------------ATPLNIE 689
                    ::||: |..:.......|:|:::.:..|                      ..||||.
Human   200 GGRRDYTVQVQLRLCLAETSCPQEDNYPNSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNIT 264

  Fly   690 RSEKNSTALRPLYLKAVCQPGRNTLQLT-ASSCCCSHLFVLQLVHRPSVRQVLQTLHKRNLLPLE 753
            ...:.|:|:            .|.:.:: ||....::...:.||.:.:...:||.|..:.:...:
Human   265 SLVRLSSAV------------PNQISISWASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPD 317

  Fly   754 HSVQKIKRNLSQPEANAGPD---ATPQQQQQQGGGQQCAKISLKCPITKSRIRLPARGHECKHVQ 815
            ||...||..|:     |.||   ||..           .::||.||:.|.|:.:|.|...|.|:|
Human   318 HSRALIKEKLT-----ADPDSEIATTS-----------LRVSLMCPLGKMRLTIPCRAVTCTHLQ 366

  Fly   816 CFDLEAYLMINSERGSWRCPECSKSAITDTLEIDQYIWAILNTLGNSDVDEVIIDSSANWRALQH 880
            |||...||.:|.::.:|.||.|.|.|..::|.:|.....|||..  |||||:......:|..::.
Human   367 CFDAALYLQMNEKKPTWICPVCDKKAAYESLILDGLFMEILNDC--SDVDEIKFQEDGSWCPMRP 429

  Fly   881 NGGMPNAPPPSNVPSNPSGGSGSNSGNGSVNPTLPVIKQELCDDIAKVMSPGSTQLPTWDSAQAM 945
            .   ..|...|:.|......|...|...||.......|:::  |:..:....|:.......|:..
Human   430 K---KEAMKVSSQPCTKIESSSVLSKPCSVTVASEASKKKV--DVIDLTIESSSDEEEDPPAKRK 489

  Fly   946 SPYNMHDMNSIASGNMMGNGGNTNQHGNRSSYDGFSGNHSDGSGGLPGGDGGVNSLDQLNAMEKS 1010
            ..:.....:|...|.:|                     :...|..:|    .|.|:|.. |:..|
Human   490 CIFMSETQSSPTKGVLM---------------------YQPSSVRVP----SVTSVDPA-AIPPS 528

  Fly  1011 LSDQMPHTPHTPGAASHPMTPG--------------GPPSVSSSHNEPISGG-----TPNANGSG 1056
            |:|......|||.::.....||              .||....|...|::..     |.:::.|.
Human   529 LTDYSVPFHHTPISSMSSDLPGLDFLSLIPVDPQQYCPPMFLDSLTSPLTASSTSVTTTSSHESS 593

  Fly  1057 SATNGSGNNN-----SSTGHNSP 1074
            :..:.|.:.:     :|:|.|.|
Human   594 THVSSSSSRSETGVITSSGSNIP 616

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tnaNP_001368945.1 Med15 216..>604 CDD:312941 16/68 (24%)
SP-RING_ZMIZ 792..839 CDD:438445 21/46 (46%)
PIAS2NP_001340963.1 SAP 11..45 CDD:128789
LXXLL motif 19..23
PINIT 149..297 CDD:464136 27/161 (17%)
SP-RING_PIAS2 338..397 CDD:438468 23/69 (33%)
SUMO1-binding 467..473 1/7 (14%)
Nuclear localization signal. /evidence=ECO:0000250 484..492 1/7 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 580..622 7/37 (19%)
Blue background indicates that the domain is not in the aligned region.

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