Protein Alignment tna and PIAS1

DIOPT Version :9

• Sequence 1: NP_001368945.1
• Gene: tna / 39217
• FlyBaseID: FBgn0026160
• Length: 1186
• Species: Drosophila melanogaster
• Sequence 2: XP_011520428.1
• Gene: PIAS1 / 8554
• HGNCID: 2752
• Length: 660
• Species: Homo sapiens
• Alignment Length: 631
• Identity: 136/631 - (21%)
• Similarity: 215/631 - (34%)
• Gaps: 204/631 - (32%)

  Fly   572 NYQHSPVPGNPTP---------------PLTPA--------CSVPYVSP-----NPD-------- 600
            |...||:|...:|               ||.|.        ..:|:::.     :||
Human    88 NVHSSPMPATLSPSTIPQLTYDGHPASSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPF 152

  Fly   601 -------IKP---PMDNSEEMRLT-FPVRDGIILAPFRLLHNLSVSNHVFHLKQNVYNTLMCRND 654
                   |||   ..|||:..|.| |    ...|.| :.:..:|.|..:...|        |...
Human   153 YDLLDELIKPTSLASDNSQRFRETCF----AFALTP-QQVQQISSSMDISGTK--------CDFT 204

  Fly   655 LELQLK-CFHQDDRQMNTNWPHTVTVSAN----------------------ATPLNIERSEKNST 696
            :::||: |..:.......::|..:.|..|                      :.|:||....:.||
Human   205 VQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSLPGYLPPTKNGVEPKRPSRPINITSLVRLST 269

  Fly   697 AL-RPLYLKAVCQPGRNTLQLTASSCCCSHLFVLQLVHRPSVRQVLQTLHKRNLLPLEHSVQKIK 760
            .: ..:.:....:.|||            :...:.||.:.|...:||.|..:.:...:||...||
Human   270 TVPNTIVVSWTAEIGRN------------YSMAVYLVKQLSSTVLLQRLRAKGIRNPDHSRALIK 322

  Fly   761 RNLSQPEANAGPD---ATPQQQQQQGGGQQCAKISLKCPITKSRIRLPARGHECKHVQCFDLEAY 822
            ..|:     |.||   ||..           .::||.||:.|.|:.:|.|...|.|:||||...|
Human   323 EKLT-----ADPDSEIATTS-----------LRVSLLCPLGKMRLTIPCRALTCSHLQCFDATLY 371

  Fly   823 LMINSERGSWRCPECSKSAITDTLEIDQYIWAILNTLGNSDVDEVIIDSSANWRALQ-------- 879
            :.:|.::.:|.||.|.|.|..:.|.||.....||...  :|.||:.......|..::
Human   372 IQMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYC--TDCDEIQFKEDGTWAPMRSKKEVQEV 434

  Fly   880 ---HNG--GMPNAPPPSNVPSNPSGGS------------GSNSGN-----------GSVNPTLPV 916
               :||  |..::.....|.|:....:            .|:|..           .|::||.|:
Human   435 SASYNGVDGCLSSTLEHQVASHHQSSNKNKKVEVIDLTIDSSSDEEEEEPSAKRTCPSLSPTSPL 499

  Fly   917 IKQELCDDIAKVMSPGS--TQLPTWDSA---------------QAMSPYNMH--DMNSIASGNMM 962
            ..:.:. .:....||.|  ..||..|::               ....||::.  |.....||:
Human   500 NNKGIL-SLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTPMPYDLQGLDFFPFLSGD-- 561

  Fly   963 GNGGNTNQHGNRSSYDGFSGNHSDGSGGLPGG-----DGGVNSLDQLNAMEKSLSDQMPHTPHTP 1022
                  |||.|.|.....:...||....|...     ......||||:|               .
Human   562 ------NQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSA---------------G 605

  Fly  1023 GAASHPMTPGGPPSVSSSHNEPISGGTPNANGSGSATNGSGNNNSS 1068
            |:.|.|.|.|   |.|.|::..:|..:...:.|.:.||.|..:.:|
Human   606 GSTSLPTTNG---SSSGSNSSLVSSNSLRESHSHTVTNRSSTDTAS 648

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tna	NP_001368945.1	Med15	216..>604	CDD:312941	14/77 (18%)
		SP-RING_ZMIZ	792..839	CDD:319705	20/46 (43%)
PIAS1	XP_011520428.1	SAP	20..54	CDD:128789
		PINIT	144..280	CDD:291022	27/148 (18%)
		zf-MIZ	340..388	CDD:280964	20/47 (43%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3884
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.840