Protein Alignment tna and SIZ1

DIOPT Version :9

• Sequence 1: NP_001368945.1
• Gene: tna / 39217
• FlyBaseID: FBgn0026160
• Length: 1186
• Species: Drosophila melanogaster
• Sequence 2: NP_010697.3
• Gene: SIZ1 / 852018
• SGDID: S000002817
• Length: 904
• Species: Saccharomyces cerevisiae
• Alignment Length: 597
• Identity: 124/597 - (20%)
• Similarity: 226/597 - (37%)
• Gaps: 124/597 - (20%)

  Fly   624 APFRLLHNLSVSNHVFHLKQNVYNTLMCRNDLELQ------LKCFHQDDRQMNTNWPHTVTVSAN 682
            |.:.||.|.: |.|..:|...:.|.|..|.:..:|      |:|             :.|.:..|
Yeast   214 ADYNLLSNPN-SKHRLYLFSGMINPLGSRGNEPIQFPFPNELRC-------------NNVQIKDN 264

  Fly   683 ATPLNIERSEKNSTALRPLYLKAVCQPGRNTLQLTASSCCCSHLFVLQLVHRPSVRQVLQTLHKR 747
            ......:........|.| :||...|  :|.::|..:.....:.....:|...:..|:|:.:.:.
Yeast   265 IRGFKSKPGTAKPADLTP-HLKPYTQ--QNNVELIYAFTTKEYKLFGYIVEMITPEQLLEKVLQH 326

  Fly   748 NLLPLEHSVQKIKRNLSQPEANAGPDATPQQQQQQGGGQQCAKISLKCPITKSRIRLPARGHECK 812
            ..:..:.::..:|:.|             ::.::.|.......:||:|||:.:|::.|::...||
Yeast   327 PKIIKQATLLYLKKTL-------------REDEEMGLTTTSTIMSLQCPISYTRMKYPSKSINCK 378

  Fly   813 HVQCFDLEAYLMINSERGSWRCPECSKSAITDTLEIDQYIWAILNTLGNSDVDEVIIDSSANWRA 877
            |:||||...:|....:..:|:||.|......:.|.|.:::..||... ..:|::|.:.|...|.|
Yeast   379 HLQCFDALWFLHSQLQIPTWQCPVCQIDIALENLAISEFVDDILQNC-QKNVEQVELTSDGKWTA 442

  Fly   878 LQHNGGMPNAPPPSNVPSNPSGGSGSNSGNGSVNPTLPVIKQELCDDIAKVMSPGSTQLPTWDSA 942
            :..:....::.......|...|.|.|:....|.:|:.|:|.....||               |..
Yeast   443 ILEDDDDSDSDSNDGSRSPEKGTSVSDHHCSSSHPSEPIIINLDSDD---------------DEP 492

  Fly   943 QAMSPY--NMHDMNSIASGNMMGNGGNTNQHGNRSSYDGFSGNHSDGSGGLPGGDGGVNSLDQLN 1005
            ...:|:  |.||     ..|...|..|.|...|..|::..:.|:::.:.         |:.|..|
Yeast   493 NGNNPHVTNNHD-----DSNRHSNDNNNNSIKNNDSHNKNNNNNNNNNN---------NNNDNNN 543

  Fly  1006 AMEKSLSDQMPHTPHTPGAASHPMTPGGPPSVSSSHNEPISGGTPNANGSGSATNGSGNNNSST- 1069
            ::|.  :|...:..|..|:.|:  ||      |.:|.:.:.....:.:........:.|:..||
Yeast   544 SIEN--NDSNSNNKHDHGSRSN--TP------SHNHTKNLMNDNDDDDDDRLMAEITSNHLKSTN 598

  Fly  1070 -------GHNSPQ----------------TPGT----PSRMGGGMGGSGSADSQQQQQEQLLNSL 1107
                   |.::|.                ||.|    |..:|......|         :||.|.|
Yeast   599 TDILTEKGSSAPSRTLDPKSYNIVASETTTPVTNRVIPEYLGNSSSYIG---------KQLPNIL 654

  Fly  1108 MSSQTQLKFSESDLSAELQSFDAAAAA---INDTAHDLNLLQDVDPMEILSYLDPQ----PDLNT 1165
              .:|.|..:..|.|:.|.|.|.:.::   .|..::..:......|:..:|.|||:    ||...
Yeast   655 --GKTPLNVTAVDNSSHLISPDVSVSSPTPRNTASNASSSALSTPPLIRMSSLDPRGSTVPDKTI 717

  Fly  1166 PPSSGSSNNNAS 1177
            .|...|::..||
Yeast   718 RPPINSNSYTAS 729

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tna	NP_001368945.1	Med15	216..>604	CDD:312941
		SP-RING_ZMIZ	792..839	CDD:319705	19/46 (41%)
SIZ1	NP_010697.3	SAP	34..68	CDD:128789
		PINIT	176..311	CDD:405075	22/113 (19%)
		SP-RING_ScSiz_like	358..405	CDD:319707	19/46 (41%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157343826
Domainoid	1	1.000	57	1.000	Domainoid score	I2648
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10782
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3884
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	5	4.960