DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tna and SIZ1

DIOPT Version :9

Sequence 1:	NP_001368945.1	Gene:	tna / 39217	FlyBaseID:	FBgn0026160	Length:	1186	Species:	Drosophila melanogaster
Sequence 2:	NP_001119465.1	Gene:	SIZ1 / 836163	AraportID:	AT5G60410	Length:	885	Species:	Arabidopsis thaliana

Alignment Length:	787	Identity:	175/787 - (22%)
Similarity:	276/787 - (35%)	Gaps:	221/787 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   543 MQQAGGMCPAGPGAVAT-TGNPYQNQGFQQNYQHSPVPGNPTPPLTPACSVPYVSPNP------- 599
            ||.:|....|..|.|:: |.|             ..|.|.|..|..|...|..|..|.
plant    76 MQVSGASDLASKGQVSSDTSN-------------LKVKGEPEDPFQPEIKVRCVCGNSLETDSMI 127

  Fly   600 -----------------------DIKPPMDNS---EEMRLT----FPVRDGIILAPFRLLHNLSV 634
                                   |..||:..|   |..|||    |.|.....|:|.||... ::
plant   128 QCEDPRCHVWQHVGCVILPDKPMDGNPPLPESFYCEICRLTRADPFWVTVAHPLSPVRLTAT-TI 191

  Fly   635 SNHVFHLKQNVYNT---------LMCRNDLELQLKCFHQDDRQM-NTNWPHTVTVSANATPLNIE 689
            .|......|:|..|         |:.:.:.::|..|...:|:.: ...||....:..|..|
plant   192 PNDGASTMQSVERTFQITRADKDLLAKPEYDVQAWCMLLNDKVLFRMQWPQYADLQVNGVP---- 252

  Fly   690 RSEKNSTALRPLYLKAVCQPGRNTLQLTA-------SSCC-----------------CSHLFVLQ 730
                         ::|:.:||...|.:..       :||.                 |   |.::
plant   253 -------------VRAINRPGGQLLGVNGRDDGPIITSCIRDGVNRISLSGGDVRIFC---FGVR 301

  Fly   731 LVHRPSVRQVLQTLHKRNLLPLEHSVQKIKRNLSQPEANAGPDATPQQQQQQGGGQQCAK----- 790
            ||.|.:::|||      ||:|.|...:..:..|::.....|          .|||...|.
plant   302 LVKRRTLQQVL------NLIPEEGKGETFEDALARVRRCIG----------GGGGDDNADSDSDI 350

  Fly   791 --------ISLKCPITKSRIRLPARGHECKHVQCFDLEAYLMINSERGSWRCPECSKSAITDTLE 847
                    ::|:||::.|||::..|...|.|:.||||:.::.:|.....|:||.|.|:...:.:.
plant   351 EVVADFFGVNLRCPMSGSRIKVAGRFLPCVHMGCFDLDVFVELNQRSRKWQCPICLKNYSVEHVI 415

  Fly   848 IDQYIWAILNTLGNSD--VDEVIIDSSANWRA-------LQHNGGMP--NAPPPSNVPSN----- 896
            :|.|...|.:.:.:.|  |.|:.:....:||.       .:..|.:.  :||..|..||.
plant   416 VDPYFNRITSKMKHCDEEVTEIEVKPDGSWRVKFKRESERRELGELSQWHAPDGSLCPSAVDIKR 480

  Fly   897 -----PSGGSGSNSGNGSVNPTLPVIKQELCDDIAKVMSPGSTQLPTWDSAQAMSPY---NMHDM 953
                 |....|.:.|...:.  |.:.|..  :.|.:|..|.:..|.: .:.|....|   |:..|
plant   481 KMEMLPVKQEGYSDGPAPLK--LGIRKNR--NGIWEVSKPNTNGLSS-SNRQEKVGYQEKNIIPM 540

  Fly   954 NSIASGN-MMGNGGNTNQH--------GNRSSYDGFSGNHSDGSGGLP----GGDGGVNSLDQLN 1005
            :|.|:|: ..|:..:.||.        .|....|..|.| .|.....|    .|:||.|.:..|
plant   541 SSSATGSGRDGDDASVNQDAIGTFDFVANGMELDSISMN-VDSGYNFPDRNQSGEGGNNEVIVL- 603

  Fly  1006 AMEKSLSDQMPHTPHTPGAA-SHPMTPGG------PPSVSSSHNEPISGGTPNANGSGSATNGSG 1063
                |.||.......|||.| |...|.||      ||.:.:|:||     .|::...||:..|..
plant   604 ----SDSDDENDLVITPGPAYSGCQTDGGLTFPLNPPGIINSYNE-----DPHSIAGGSSGLGLF 659

  Fly  1064 NNNS-------STGHNSPQTPG-----TPSRMGGGMGGSGSADSQQQQQEQLLNSLMSSQTQLKF 1116
            |::.       |....:|:.||     :.:.:.||:.|...........|......|:.:|.:
plant   660 NDDDEFDTPLWSFPSETPEAPGFQLFRSDADVSGGLVGLHHHSPLNCSPEINGGYTMAPETSM-- 722

  Fly  1117 SESDLSAELQSFDAAAAAINDTAHDLNLLQDVDPMEILSYLDPQPDLNTPPSSG------SSNNN 1175
                .|..:.......:..||...|..|....|...:..:|..:||.:.  .||      .||..
plant   723 ----ASVPVVPGSTGRSEANDGLVDNPLAFGRDDPSLQIFLPTKPDASA--QSGFKNQADMSNGL 781

  Fly  1176 ASDDLLA 1182
            .|:|.::
plant   782 RSEDWIS 788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tna	NP_001368945.1	Med15	216..>604	CDD:312941	17/91 (19%)
tna	NP_001368945.1	SP-RING_ZMIZ	792..839	CDD:319705	18/46 (39%)
SIZ1	NP_001119465.1	SAP	14..45	CDD:128789
		PHD_Bye1p_SIZ1_like	114..165	CDD:277045	7/50 (14%)
		SP-RING_Siz_plant	360..408	CDD:319706	18/47 (38%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10782
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.000