Protein Alignment tna and Pias3

DIOPT Version :9

• Sequence 1: NP_001368945.1
• Gene: tna / 39217
• FlyBaseID: FBgn0026160
• Length: 1186
• Species: Drosophila melanogaster
• Sequence 2: NP_113972.2
• Gene: Pias3 / 83614
• RGDID: 708413
• Length: 628
• Species: Rattus norvegicus
• Alignment Length: 579
• Identity: 133/579 - (22%)
• Similarity: 199/579 - (34%)
• Gaps: 144/579 - (24%)

  Fly   575 HSPVPGNPTPPLTPACSVPY-------VSPNPDIKPPMDNSEEMRLTFPVRDGIILAPFRLLHNL 632
            |.|:| .|..|......:|:       :.|...........||...||      .|.|.:|...|
  Rat   116 HPPLP-QPVHPDVTMKPLPFYEVYGELIRPTTLASTSSQRFEEAHFTF------ALTPQQLQQIL 173

  Fly   633 SVSNHVFHLKQNVYNTLMCRNDLELQLK-CFHQDDRQMNTNWPHTVTVSAN-------------- 682
            :        .:.|.....|...:::||: |..:........:|..:.|..|
  Rat   174 T--------SREVLPGAKCDYTIQVQLRFCLCETSCPQEDYFPPNLFVKVNGKLCPLPGYLPPTK 230

  Fly   683 --------ATPLNI-ERSEKNSTALRPLYLKAVCQPGRNTLQLTASSCCCSHLFVLQLVHRPSVR 738
                    :.|:|| ..:..::|....:.:....:.|||            :...:.||.:.:..
  Rat   231 NGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRN------------YSLSVYLVRQLTAG 283

  Fly   739 QVLQTLHKRNLLPLEHSVQKIKRNLSQPEANAGPD---ATPQQQQQQGGGQQCAKISLKCPITKS 800
            .:||.|..:.:...:||...||..|:     |.||   ||..           .::||.||:.|.
  Rat   284 TLLQKLRAKGIRNPDHSRALIKEKLT-----ADPDSEVATTS-----------LRVSLMCPLGKM 332

  Fly   801 RIRLPARGHECKHVQCFDLEAYLMINSERGSWRCPECSKSAITDTLEIDQYIWAILNTLGNSDVD 865
            |:.:|.|...|.|:|.||...||.:|.::.:|.||.|.|.|..::|.||.....|||:.  ||.|
  Rat   333 RLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKKAPYESLIIDGLFMEILNSC--SDCD 395

  Fly   866 EVIIDSSANWRALQHNGGMPNAPPPSNVPSNPSGGSGSNSGNGSVNPTLPVIKQELCDDIAKVMS 930
            |:......:|..::.........||.....:....|....||.|.|.     |:....|:....|
  Rat   396 EIQFMEDGSWCPMKPKKEASEVCPPPGYGLDGLQYSPVQEGNQSENK-----KRVEVIDLTIESS 455

  Fly   931 PGSTQLPTWDSAQAMSPYNMH-DMNSIASGNMMGN-GGNTNQHGN----RSSYDGFSGNHSDGSG 989
            .....||         |...| .:.|.|...:.|: |..|:.|..    ||...|..|  ||...
  Rat   456 SDEEDLP---------PTKKHCPVTSAAIPALPGSKGALTSGHQPSSVLRSPAMGTLG--SDFLS 509

  Fly   990 GLP----------GGDGGVNSLDQLNAME-----------KSLSDQ--MPHTPHTPGAASHPMTP 1031
            .||          |.|  :..||..:.::           .||.:|  :.|.....|...|.:
  Rat   510 SLPLHEYPPAFPLGAD--IQGLDLFSFLQTESQHYSPSVITSLDEQDTLGHFFQFRGTPPHFL-- 570

  Fly  1032 GGP--PSVSSSHNE----PISGGTPNANGSGSATNGSGNNNSSTGHNSPQTPGTPSRMG 1084
             ||  |::.|||..    |..|...:....||:..        .||..| .|..||..|
  Rat   571 -GPLAPTLGSSHRSATPAPAPGRVSSIVAPGSSLR--------EGHGGP-LPSGPSLTG 619

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tna	NP_001368945.1	Med15	216..>604	CDD:312941	7/35 (20%)
		SP-RING_ZMIZ	792..839	CDD:319705	20/46 (43%)
Pias3	NP_113972.2	Interaction with CCAR2. /evidence=ECO:0000250|UniProtKB:Q9Y6X2	1..200		20/98 (20%)
		SAP	11..>36	CDD:128789
		LXXLL motif	19..23
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..95
		PINIT	126..263	CDD:291022	22/150 (15%)
		zf-MIZ	323..371	CDD:280964	20/47 (43%)
		SUMO1-binding. /evidence=ECO:0000250	450..460		1/9 (11%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	573..618		14/53 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810