DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tna and pias2

DIOPT Version :9

Sequence 1:	NP_001368945.1	Gene:	tna / 39217	FlyBaseID:	FBgn0026160	Length:	1186	Species:	Drosophila melanogaster
Sequence 2:	XP_031757544.1	Gene:	pias2 / 779910	XenbaseID:	XB-GENE-988474	Length:	621	Species:	Xenopus tropicalis

Alignment Length:	582	Identity:	135/582 - (23%)
Similarity:	211/582 - (36%)	Gaps:	164/582 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   551 PAGP-GAV--ATTGNPYQNQGFQQNYQHSPVPGNPTPPLTPACSVPYVSPNPDIKPPMDNSEEMR 612
            ||.| |:|  ..|..|::.|      |.||             |:|.|.|:..:|
Frog   113 PASPLGSVLLQDTKAPFEIQ------QLSP-------------SIPPVHPDVHLK---------- 148

  Fly   613 LTFPVRD--GIILAPFRLLHN----LSVSNHVFHL-KQNVYNTLMCRN---------DLELQLK- 660
             :.|..|  .:::.|..|:.|    ......:|.| .|.|...::.|:         .:::||:
Frog   149 -SLPFYDVLDVLIKPTSLVQNTLQRFQEKFFIFALTPQQVREVVISRDYMPGGRRDYSVQVQLRL 212

  Fly   661 CFHQDDRQMNTNWPHTVTVSAN----------------------ATPLNIERSEKNSTALRPLYL 703
            |..:.......|:|.::.:..|                      ..||||....:.|:|:
Frog   213 CLAETSCPQEDNYPSSLCIKVNGKLFPLPGCAVPPKNGVEQKRPGRPLNITSLVRLSSAV----- 272

  Fly   704 KAVCQPGRNTLQLTASSCCCSHLFVLQLVHRPSVRQVLQTLHKRNLLPLEHSVQKIKRNLSQPEA 768
                 |.:.::. .||....::...:.||.:.:...:||.|..:.:...:||...||..|:
Frog   273 -----PNQVSIS-WASEIGKNYSMSVYLVRQLTSAVLLQKLKMKGIRNPDHSRALIKEKLT---- 327

  Fly   769 NAGPD---ATPQQQQQQGGGQQCAKISLKCPITKSRIRLPARGHECKHVQCFDLEAYLMINSERG 830
             |.||   ||..           .::||.||:.|.|:.:|.|...|.|:||||...||.:|.::.
Frog   328 -ADPDSEIATTS-----------LRVSLMCPLGKMRLTIPCRAVTCSHLQCFDAALYLQMNEKKP 380

  Fly   831 SWRCPECSKSAITDTLEIDQYIWAILNTLGNSDVDEVIIDSSANWRALQHNGGMPNAPPPSNVPS 895
            :|.||.|.|.|..::|.||.....|||..  |||||:......:|..::         |.....:
Frog   381 TWICPVCDKKASYESLIIDGLFMEILNQC--SDVDEIKFQQDGSWCPMR---------PKKEPMT 434

  Fly   896 NPSGGSGSNSGNGSVNPTLPVI---------KQELCDDIAKVMSPGSTQLP--------TWDSAQ 943
            :||.......|.|.::.....:         |.|:. |:....|....:.|        |.....
Frog   435 SPSTQYPHIEGAGVISKICSAVEGGETTRKNKAEVI-DLTLESSSDDDEPPAKKECVYLTESQEA 498

  Fly   944 AMSPYNMHDMNSIASGNMMGNGGNTNQHGNRSSY-DGFSGNHSDGSGG----LPGGDGGVNSLDQ 1003
            ||.....:..:||..|.:.|..... .|.:.:.| |.|   |.....|    |||.|  ..||..
Frog   499 AMKGVLSYQPSSIRVGKVAGIESEP-MHPSMAGYADHF---HHPAIAGISAELPGLD--FLSLVS 557

  Fly  1004 LNAME-------KSLSDQMPHTPHTPGAASHPMTPGGPPSVSSSHNEPIS-----GGTPNAN 1053
            ::..:       .||:..|| |.|..|.         |.:.||.|....|     ..:|||:
Frog   558 MDPQQYYPPMFLDSLTSAMP-TSHVTGK---------PRTWSSRHESHSSEENDLPPSPNAS 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tna	NP_001368945.1	Med15	216..>604	CDD:312941	16/55 (29%)
tna	NP_001368945.1	SP-RING_ZMIZ	792..839	CDD:319705	21/46 (46%)
pias2	XP_031757544.1	SAP	11..45	CDD:128789
		PINIT	146..295	CDD:405075	26/170 (15%)
		SP-RING_PIAS	342..389	CDD:319704	21/46 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000