DRSC/TRiP Functional Genomics Resources

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Protein Alignment tna and Pias1

DIOPT Version :10

Sequence 1:NP_001368945.1 Gene:tna / 39217 FlyBaseID:FBgn0026160 Length:1186 Species:Drosophila melanogaster
Sequence 2:NP_062637.2 Gene:Pias1 / 56469 MGIID:1913125 Length:651 Species:Mus musculus


Alignment Length:672 Identity:145/672 - (21%)
Similarity:209/672 - (31%) Gaps:261/672 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly   572 NYQHSPVP--------------GNP-TPPLTPA--------CSVPYVSP-----NPD-------- 600
            |...||:|              |:| :.||.|.        ..:|:::.     :||        
Mouse    79 NVHSSPMPPTLSPSTIPQLTYDGHPASSPLLPVSLLGPKHELELPHLTSALHPVHPDIKLQKLPF 143

  Fly   601 -------IKP---PMDNSEEMRLT-FPVRDGIILAPFRLLHNLSVSNHVFHLKQNVYNTLMCRND 654
                   |||   ..|||:..|.| |    ...|.| :.:..:|.|..:...|        |...
Mouse   144 YDLLDELIKPTSLASDNSQRFRETCF----AFALTP-QQVQQISSSMDISGTK--------CDFT 195

  Fly   655 LELQLK-CFHQDDRQMNTNWPHTVTVSANATPLNIERSEKNSTALRPLYL---KAVCQPGR---- 711
            :::||: |..:.......::|..:.|..|..|.::           |.||   |...:|.|    
Mouse   196 VQVQLRFCLSETSCPQEDHFPPNLCVKVNTKPCSL-----------PGYLPPTKNGVEPKRPSRP 249

  Fly   712 -NTLQLTASSCCCSHLFVLQ--------------LVHRPSVRQVLQTLHKRNLLPLEHSVQKIKR 761
             |...|...|....:..|:.              ||.:.|...:||.|..:.:...:||...||.
Mouse   250 INITSLVRLSTTVPNTIVVSWTAEIGRTYSMAVYLVKQLSSTVLLQRLRAKGIRNPDHSRALIKE 314

  Fly   762 NLSQPEANAGPD---ATPQQQQQQGGGQQCAKISLKCPITKSRIRLPARGHECKHVQCFDLEAYL 823
            .|:     |.||   ||..           .::||.||:.|.|:.:|.|...|.|:||||...|:
Mouse   315 KLT-----ADPDSEIATTS-----------LRVSLLCPLGKMRLTIPCRALTCSHLQCFDATLYI 363

  Fly   824 MINSERGSWRCPECSKSAITDTLEIDQYIWAILNTLGNSDVDEVIIDSSANW------------- 875
            .:|.::.:|.||.|.|.|..:.|.||.....||...  :|.||:......:|             
Mouse   364 QMNEKKPTWVCPVCDKKAPYEHLIIDGLFMEILKYC--TDCDEIQFKEDGSWAPMRSKKEVQEVT 426

  Fly   876 -----------RALQHNGGMPN-------------------------APP-----PSNVPSNPSG 899
                       ..|:|.....|                         .||     ||..|::|..
Mouse   427 ASYNGVDGCLSSTLEHQVASHNQSSNKNKKVEVIDLTIDSSSDEEEEEPPAKRTCPSLSPTSPLS 491

  Fly   900 GSG-----SNSGNGSVNPTLPV-----IKQELCDDIAKV--MSPGSTQLPTWDSAQAMSPYNMH- 951
            ..|     ..:...|..|:||.     |...|..|....  |:|              .||::. 
Mouse   492 NKGILSLPHQASPVSRTPSLPAVDTSYINTSLIQDYRHPFHMTP--------------MPYDLQG 542

  Fly   952 -DMNSIASGNMMGNGGNTNQHGNRSSYDGFSGNHSDGSGGLPGG-----DGGVNSLDQLNAMEKS 1010
             |.....||:        |||.|.|.....:...||....|...     ......||||:|    
Mouse   543 LDFFPFLSGD--------NQHYNTSLLAAAAAAVSDDQDLLHSSRFFPYTSSQMFLDQLSA---- 595

  Fly  1011 LSDQMPHTPHTPGAASHPMTPGGPPSVSSSHNEPISGGTPNANGSGSATNGS--GNNNSSTGHNS 1073
                                 ||..|:            |..|||.|.:|.|  .:|:....|  
Mouse   596 ---------------------GGSTSL------------PATNGSSSGSNSSLVSSNSLRESH-- 625

  Fly  1074 PQTPGTPSRMGGGMGGSGSADS 1095
                      |.|:....|||:
Mouse   626 ----------GHGVASRSSADT 637

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tnaNP_001368945.1 Med15 216..>604 CDD:312941 15/77 (19%)
SP-RING_ZMIZ 792..839 CDD:438445 20/46 (43%)
Pias1NP_062637.2 Required for interaction with MSX1. /evidence=ECO:0000269|PubMed:16600910 2..200 27/133 (20%)
SAP 11..45 CDD:128789
LXXLL motif 19..23
Nuclear localization signal. /evidence=ECO:0000255 56..64
PINIT 140..286 CDD:464136 33/169 (20%)
SP-RING_PIAS1 327..386 CDD:438467 22/69 (32%)
Nuclear localization signal. /evidence=ECO:0000255 368..380 4/11 (36%)
SUMO1-binding. /evidence=ECO:0000250 462..473 0/10 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 465..511 9/45 (20%)
4 X 4 AA repeats of N-T-S-L 520..615 31/153 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 600..630 12/53 (23%)
Blue background indicates that the domain is not in the aligned region.

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