Protein Alignment tna and zmiz1a

DIOPT Version :9

• Sequence 1: NP_001368945.1
• Gene: tna / 39217
• FlyBaseID: FBgn0026160
• Length: 1186
• Species: Drosophila melanogaster
• Sequence 2: XP_005156910.1
• Gene: zmiz1a / 561061
• ZFINID: ZDB-GENE-080220-27
• Length: 1080
• Species: Danio rerio
• Alignment Length: 1192
• Identity: 396/1192 - (33%)
• Similarity: 509/1192 - (42%)
• Gaps: 374/1192 - (31%)

  Fly    72 GKKNDEMNQQAGSSRAPATGGQISP--PGATTVGVEQQQHLQQQHQQQYYNQQQQQQQQQYQQQH 134
            |..|...:|..|:..|...    :|  ||...:|.....:....:..|:..||||...:....|
Zfish   184 GVTNTSQSQVLGNPMANTN----NPMNPGGNALGSGMSANNPGINSPQFPGQQQQFSTKGGSNQ- 243

  Fly   135 QRDNFLAYQQQQQQQQQQQQQLQRSGGGG--GNFMLGNDLVGGDSLRSLNNTFGPNSEFTSLGGA 197
                  ||.||....:.     ...||||  |::..|.:...|..:.....   |.|:||.  .|
Zfish   244 ------AYMQQSMYGRP-----GHPGGGGFAGSYPGGPNAPSGMGMPPHTR---PPSDFTQ--PA 292

  Fly   198 NSSASSSLSGLSSSSSQGYTGMVAASQQHQQQQPHHHQQQQQQQQQQHMGSMDAMGGYSQMGGGM 262
            .::|:::::..:::::...|..|||.|:..:.                      |..|:|:....
Zfish   293 AAAAAAAVAAAAATATATATATVAALQETNKD----------------------MNQYNQVCSSF 335

  Fly   263 HPGPNSGMMGNMNGQYMN--GGSG----QGGYNGAQGMGMGYGGGGSMGPQRHHQMTPMNQMQNM 321
            ..||..|    .|.|:||  |..|    .||.|.| .||.|.......||       ||.  .|.
Zfish   336 QMGPTQG----YNSQFMNQPGPRGPPSMAGGMNPA-AMGGGMNSSNMSGP-------PMG--MNQ 386

  Fly   322 SMGPGVGGSGGMGGGMNPLQQQAAQQQMGGMNPMAKMQGMANGGYPQQAPPSLTQQQQQQQQRRM 386
            ..|||:|..||.|                        |.|...|||...|.|:..|
Zfish   387 PRGPGMGPFGGHG------------------------QRMPQQGYPGPRPQSMPMQ--------- 418

  Fly   387 APYPHPQMHMAQKRAAAGVGGAGGMYPGNPMQQQQAQMYGNQQMHPGSGGGVPLPMQAGGAGNGY 451
                                |....|||.|       .||.||                     :
Zfish   419 --------------------GTKRPYPGEP-------NYGGQQ---------------------F 435

  Fly   452 GRSGPMGVGNGGYGRMSAGNGMGPTGGPVMGPMGPGGMTAGGMGPGPGCMSQQRFMPQGSGGGMP 516
            |.:|......|.|...:|..       |:..|..||                ||...|.|.|..|
Zfish   436 GPNGQFPNQQGQYPNPNASR-------PLPSPNYPG----------------QRMPGQQSTGQYP 477

  Fly   517 GVGYGGVGGAASHQGQFY---PGSGQSAGMQQAGGMCPAGPGAVATTGNPYQNQGFQQNYQHSPV 578
            ..|.        ..||:|   |.:||:...  :||    |.|.....|.|.|    ..||.||||
Zfish   478 PTGV--------PMGQYYKQEPFNGQNNNF--SGG----GYGYSQGNGPPRQ----VVNYPHSPV 524

  Fly   579 PGNPTPPLTPACSV-PYVSPNPDIKPPM----------------DNSEEMRLTFPVRDGIILAPF 626
            |||||||:||..|: ||:||:.|:|||.                :.:||:|||||||||::|.||
Zfish   525 PGNPTPPMTPGSSIPPYLSPSQDVKPPFPPDMKPNMTSLPPPPNNPNEELRLTFPVRDGVVLEPF 589

  Fly   627 RLLHNLSVSNHVFHLKQNVYNTLMCRNDLELQLKCFHQDDRQMNTNWPHTVTVSANATPLNIERS 691
            ||.|||:||||||||:.:|:.|||.|:|||||.||:|.:|||||||||.:|.||.|||||.|||.
Zfish   590 RLEHNLAVSNHVFHLRPSVHQTLMWRSDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLTIERG 654

  Fly   692 EKNSTALRPLYLKAVCQPGRNTLQLTASSCCCSHLFVLQLVHRPSVRQVLQTLHKRNLLPLEHSV 756
            : |.|:.:||:||.||||||||:|:|.::||||||||||||||||||.|||.|.|:.|||.||.:
Zfish   655 D-NKTSHKPLHLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAEHCI 718

  Fly   757 QKIKRNLSQPEANAGPDATPQQQQQQGGGQQCAKISLKCPITKSRIRLPARGHECKHVQCFDLEA 821
            .|||||.|...|:.| :||  ...:.|..|...|:|||||||..||:||||||:||||||||||:
Zfish   719 TKIKRNFSSVAASTG-NAT--LNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCKHVQCFDLES 780

  Fly   822 YLMINSERGSWRCPECSKSAITDTLEIDQYIWAILNTLGNSDVDEVIIDSSANWRALQHNGGMPN 886
            ||.:|.|||:||||.|:|:|:.:.||:|||:|.|||.:.||:.:||.||.:.:||
Zfish   781 YLQLNCERGTWRCPVCNKTALLEGLEVDQYMWGILNAIQNSEFEEVNIDPTCSWR---------- 835

  Fly   887 APPP----SNVPSNPSGGSGSNSGNGSVNPTLPVIKQELCDDIAKVMSPGSTQLPTWDSAQAM-- 945
             |.|    .::..:|.|               |:.|:      .|.|||....:|......|.
Zfish   836 -PVPIKSDIHIKEDPDG---------------PLAKR------FKTMSPSQMIMPNVMDMIAQLG 878

  Fly   946 ---SPYN----MHDMNSIASGNMMGNGGNTNQHGNRSSYDG---FSGNHSDGSGGLPGGD----- 995
               |||.    .|.          ||.|.....|..:||.|   |...||:..||.|..|
Zfish   879 PGPSPYTPLPPQHG----------GNNGEYGGQGRGNSYQGHGNFDFPHSNSGGGAPMNDFMHGP 933

  Fly   996 ------GGVNSL---DQLNAMEKSLSDQMPH-----------------TPHTPGAASHPMTPGGP 1034
                  ...|||   |:  .:...:.|.|||                 :||....::.|:...||
Zfish   934 QLSHPPDVPNSLMGPDK--PLAHGMPDTMPHPVSADQSHASMQPGMHASPHPNSQSAQPLHHSGP 996

  Fly  1035 PSVSSSHNEPISGGTPNANGSGSATNGSGNNNSSTGHNSPQTPGTPSRMGGGMGGSGSADSQQQQ 1099
            || |....:|.|...|:.|                .|..|.....|| ..|..||.|.||..:.
Zfish   997 PS-SQPPRQPPSQQQPSQN----------------THPHPDMSFNPS-ADGQPGGQGPADMPEP- 1042

  Fly  1100 QEQLLNSLMSSQTQLKFSESDLSAELQSFDAAAAAINDTAHDLNLLQDVDPMEILSYLDPQPDLN 1164
                  ||            ||..||                      .:|.|:|||||| |||
Zfish  1043 ------SL------------DLLPEL----------------------ANPDELLSYLDP-PDL- 1065

  Fly  1165 TPPSSGSSNNNASDDLLATLFD 1186
              |||      ::|||| :||:
Zfish  1066 --PSS------SNDDLL-SLFE 1078

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tna	NP_001368945.1	Med15	216..>604	CDD:312941	104/397 (26%)
		SP-RING_ZMIZ	792..839	CDD:319705	36/46 (78%)
zmiz1a	XP_005156910.1	CITED	336..>463	CDD:282356	52/228 (23%)
		zf-MIZ	750..798	CDD:280964	36/47 (77%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580723
Domainoid	1	1.000	311	1.000	Domainoid score	I1288
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	457	1.000	Inparanoid score	I1555
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143293at33208
OrthoFinder	1	1.000	-	-		FOG0002880
OrthoInspector	1	1.000	-	-		otm25499
orthoMCL	1	0.900	-	-		OOG6_105005
Panther	1	1.100	-	-	O	PTHR10782
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3884
SonicParanoid	1	1.000	-	-		X2238
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.980