DRSC/TRiP Functional Genomics Resources

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Protein Alignment tna and Zmiz2

DIOPT Version :9

Sequence 1:NP_001368945.1 Gene:tna / 39217 FlyBaseID:FBgn0026160 Length:1186 Species:Drosophila melanogaster
Sequence 2:NP_082877.2 Gene:Zmiz2 / 52915 MGIID:106374 Length:920 Species:Mus musculus


Alignment Length:1176 Identity:367/1176 - (31%)
Similarity:500/1176 - (42%) Gaps:365/1176 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    72 GKKNDEMNQQAGSSRAPATGGQISPPGATTV--------GVEQQQHLQQQHQQQYYNQQQQQQQQ 128
            |..|...:|..|:...||.    ||||.:.:        .:...|.|.||               
Mouse    47 GVGNATQSQVLGNPMGPAG----SPPGGSMMPGVAGGSSALTSPQCLGQQ--------------- 92

  Fly   129 QYQQQHQRDNFLAYQQQQQQQQQQQQQLQRSGG--GGGNFMLGNDLVGGDSLRSL-NNTFGPNSE 190
                        |:.:....:...||.:...|.  ||.:|..|  ..||.:...| .:...|:::
Mouse    93 ------------AFAEGGASKSYVQQGVYGRGSYPGGSSFTTG--YAGGPAGLGLPTHAARPSTD 143

  Fly   191 FTSLGGANSSASSSLSGLSSSSSQGYTGMVAASQQHQQQQPHHHQQQQQQQQQQHMGSMDAMGGY 255
            ||     .::|:::::..:::::...|..|||.|:.|.|:                     :..|
Mouse   144 FT-----QAAAAAAMAAAAATATATATATVAALQEKQSQE---------------------LSQY 182

  Fly   256 SQMGGGMHPGPNSGMMGNMNGQYMNGGSGQGGYNGAQGMGMGYGGGGSMGPQRHHQMTPMNQMQN 320
            ..||.|.          :.|.|::.                   .||..||              
Mouse   183 GAMGTGQ----------SFNSQFLQ-------------------HGGPRGP-------------- 204

  Fly   321 MSMGPGVGGSGGMGGGMNP--LQQQA-AQQQMGGMNPMAKMQGMANGGYPQQAPPSLTQQQQQQQ 382
             |:.||:..| ||||.|.|  |...| ...:..||.|:...|.:...|||  .||        |.
Mouse   205 -SVPPGMNPS-GMGGMMGPSGLSSMAMTPTRAAGMTPLYAGQRLPQHGYP--GPP--------QG 257

  Fly   383 QRRMAPYPHPQMHMAQKRAAAGVGGAGGMYPGNPMQQQQAQMYGNQQMHPGSG---------GGV 438
            |      |.|:..:  |||.:.|      |||....|.........|..||.|         .|.
Mouse   258 Q------PLPRQGI--KRAYSEV------YPGQQYLQGGQYAANTAQYAPGPGQPPGPASSYAGH 308

  Fly   439 PLPMQAGGAGNGYGRSGPMGVGNGGYGRMSAGNGMGPTGGPVMGPMGPGGMTAGGMGPGPGCMSQ 503
            .||:|.|.|   ...|.|                 ||||                          
Mouse   309 RLPLQQGMA---QSLSAP-----------------GPTG-------------------------- 327

  Fly   504 QRFMPQGSGGGMPGVGYGGVGGAASHQGQFYPG-SGQSAGMQQAGGMCPAGPGAVATTGNPYQNQ 567
            ..:.|.....|. |..:.  ||:.|:.   .|| ||.|..:          ||            
Mouse   328 LHYKPTEQFNGQ-GASFN--GGSISYS---QPGLSGPSRSI----------PG------------ 364

  Fly   568 GFQQNYQHSPVPGNPTPPLTPACSVPYVSPN--------PDIKPPMD----------NSEEMRLT 614
                 |..||:|||||||:||:.:|||:||:        ||:||.:.          :.:|:|||
Mouse   365 -----YPSSPLPGNPTPPMTPSSNVPYMSPSQEVKSPFLPDLKPGLSSLHPSPSASVHCDELRLT 424

  Fly   615 FPVRDGIILAPFRLLHNLSVSNHVFHLKQNVYNTLMCRNDLELQLKCFHQDDRQMNTNWPHTVTV 679
            ||||||::|.||||.|||:||||||.|:.:||.|||.|.|||||.||:|.:|||||||||.:|.|
Mouse   425 FPVRDGVVLEPFRLQHNLAVSNHVFQLRDSVYKTLMLRPDLELQFKCYHHEDRQMNTNWPASVQV 489

  Fly   680 SANATPLNIERSEKNSTALRPLYLKAVCQPGRNTLQLTASSCCCSHLFVLQLVHRPSVRQVLQTL 744
            |.|||||:|||.: |.|:.:|||||.||||||||:|:|.::||||||||||||||||||.|||.|
Mouse   490 SVNATPLSIERGD-NKTSHKPLYLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGL 553

  Fly   745 HKRNLLPLEHSVQKIKRNLSQPEANAGPDATPQQQQQQGGGQQCAKISLKCPITKSRIRLPARGH 809
            .|:.|||.||.:.|||||.|    :.....||....:.|..|...|:|||||||..||:||||||
Mouse   554 LKKRLLPAEHCITKIKRNFS----SGTIPGTPGPNGEDGVEQTAIKVSLKCPITFRRIQLPARGH 614

  Fly   810 ECKHVQCFDLEAYLMINSERGSWRCPECSKSAITDTLEIDQYIWAILNTLGNSDVDEVIIDSSAN 874
            :|:|:||||||:||.:|.|||:||||.|:|:|:.:.||:|||:..||..:.|||.:|:.||.:.:
Mouse   615 DCRHIQCFDLESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMLGILIYIQNSDYEEITIDPTCS 679

  Fly   875 WRALQHNGGMPNAPPPSNVPSNPSGGSGSNSGNGSVNPTLPVIKQELCDDIAKVMSPGSTQLPTW 939
            |:.:.       ..|..::...|.|               ||:|:      .:.:||....:|: 
Mouse   680 WKPVP-------VKPDLHIKEEPDG---------------PVLKR------CRTVSPAHVLMPS- 715

  Fly   940 DSAQAMSPYNMHDMNSIASGNMMGNGG------NTNQHGNRSSYDGFSGNHSDGSGGLPGGDGGV 998
                        .|..||:   :|.|.      ........|.|.. .|::..|.|..|      
Mouse   716 ------------VMEMIAA---LGPGAAPFAPLQPPSAPTPSDYPS-QGSNFMGPGTFP------ 758

  Fly   999 NSLDQLNAMEKSLSDQMPH-TPHTPGAASHPMTPGGPPSVSSSHNEPISGGTPNANGSGSATNGS 1062
                          :..|. ||.||..|....   |||.:|...:.|.|..||:     .:|...
Mouse   759 --------------ESFPSATPTTPNLAEFTQ---GPPPISYQSDIPSSLLTPD-----KSTPCL 801

  Fly  1063 GNNNSSTGHNSP-QTPGTPSRMGGGMGGSGSADSQQQQQEQLLNSLMSSQTQLKFSESDLSAELQ 1126
            ....:..||..| ..||.|......:|.:........      |...:|:..|....:...:|| 
Mouse   802 PGQMAPAGHLDPAHNPGPPGLHTPNLGPTPGTQLHHP------NPSPASRQPLGQPNTGPISEL- 859

  Fly  1127 SFDAA-----------AAAINDTAHDLNLLQDVDPMEILSYLDPQPDLNTPPSSGSSNNNASDDL 1180
            :|:.|           |...::.|.|| |.:..:|.|:||||.| |||.|         |:||||
Mouse   860 AFNPASGMMGPPSMTGAGEASEPALDL-LPELTNPDELLSYLGP-PDLPT---------NSSDDL 913

  Fly  1181 LATLFD 1186
            | :||:
Mouse   914 L-SLFE 918

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tnaNP_001368945.1 Med15 216..>604 CDD:312941 99/408 (24%)
SP-RING_ZMIZ 792..839 CDD:319705 34/46 (74%)
Zmiz2NP_082877.2 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..22
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 243..262 9/34 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 289..308 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 317..408 41/169 (24%)
Interaction with AR. /evidence=ECO:0000250 435..506 49/71 (69%)
SP-RING_ZMIZ 597..644 CDD:319705 34/46 (74%)
SP-RING finger 600..642 CDD:319705 30/41 (73%)
PHA03307 714..>887 CDD:223039 45/225 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 732..920 59/235 (25%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 300 1.000 Domainoid score I1421
eggNOG 1 0.900 - - E1_KOG2169
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 420 1.000 Inparanoid score I1776
Isobase 1 0.950 - 0 Normalized mean entropy S4695
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002880
OrthoInspector 1 1.000 - - otm44232
orthoMCL 1 0.900 - - OOG6_105005
Panther 1 1.100 - - LDO PTHR10782
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3884
SonicParanoid 1 1.000 - - X2238
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.800

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