DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tna and pias4a

DIOPT Version :9

Sequence 1:	NP_001368945.1	Gene:	tna / 39217	FlyBaseID:	FBgn0026160	Length:	1186	Species:	Drosophila melanogaster
Sequence 2:	NP_998568.2	Gene:	pias4a / 406712	ZFINID:	ZDB-GENE-040426-2734	Length:	505	Species:	Danio rerio

Alignment Length:	502	Identity:	106/502 - (21%)
Similarity:	166/502 - (33%)	Gaps:	159/502 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   534 YPGSGQSAGMQQAGGMCPAGPGAVATTGNPYQNQGFQQNYQHSPVPGNPTPPLTPACSVPYVSPN 598
            ||....|          |.|.|    .|..|.|             |.|.|...||..|..| |.
Zfish    85 YPALNSS----------PRGTG----QGTDYLN-------------GIPKPAPPPAAEVKLV-PL 121

  Fly   599 P------DIKPPMD----NSEEMRLTFPVRDGIILAPFRLLHNLSVSNHVFHLKQNVYNTLMCRN 653
            |      .:.||.:    |||:                     |..|..||.|..|..:.:  ||
Zfish   122 PFYHNLETLLPPTELVAQNSEK---------------------LQESQCVFDLTPNQVDQI--RN 163

  Fly   654 DLELQ--LK--------CFHQDDRQMNTNWPHTVTVSANATPLNIE-RSEKNSTALRPLYLKAVC 707
            ..||:  :|        |:..........:|..:.|..|.:..::. ....|...:.|   :..|
Zfish   164 SSELRPGMKSVQVVLRICYTDSIGVQEDQYPPNIAVKVNQSYCHVPGYYPSNKPGVEP---RRPC 225

  Fly   708 QPGR-----------NTLQLTASSCCCSHLFVLQLVHRPSVRQVLQTLHKRNLLPLEHSVQKIKR 761
            :|..           |.:.:|..:....:...:.||...:..::...|...::...:...::|:.
Zfish   226 RPVNITPWLHLSTVTNRVTITWGNFGKRYSVAVYLVRVFTSGELFNQLKHCSVENPDRCRERIQD 290

  Fly   762 NLS-QPEANAGPDATPQQQQQQGGGQQCAKISLKCPITKSRIRLPARGHECKHVQCFDLEAYLMI 825
            .|. .||:......              .::||.||:.|.|:.:|.|...|.|:||||...:|.:
Zfish   291 KLRFDPESEIATTG--------------LRVSLICPLVKMRLGVPCRVLTCAHLQCFDAVFFLQM 341

  Fly   826 NSERGSWRCPECSKSAITDTLEIDQYIWAILNTLGNSDVDEVIIDSSANWRALQHNGGMPNAPPP 890
            |.::.:|.||.|.|.|..:.|.||..:..||... ..||:|:...:..:||.::.:
Zfish   342 NEKKPTWTCPVCDKPAPFELLTIDGLLSEILKET-PEDVEEIEYLTDGSWRPIRDD--------- 396

  Fly   891 SNVPSNPSGGSGSNSGNGSVNPTLPVIKQELCDDIAKVMSPGSTQLPTWDSAQAMSPYNMHDMNS 955
                     .........|..|..||:  ::|             :|.
Zfish   397 ---------KEKERERENSRTPDYPVV--DIC-------------VPE----------------- 420

  Fly   956 IASGNMMGNGGNTNQHGNRSSYDGFSGNHSDGSGGLPGGDGGVNSLD 1002
             |:|:...:.| |||.|...     ||..|.|:|...||.||...:|
Zfish   421 -ANGHSPAHSG-TNQTGKSG-----SGGASAGTGSTSGGSGGGTVVD 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tna	NP_001368945.1	Med15	216..>604	CDD:312941	18/75 (24%)
tna	NP_001368945.1	SP-RING_ZMIZ	792..839	CDD:319705	20/46 (43%)
pias4a	NP_998568.2	SAP	12..46	CDD:128789
		LXXLL motif. /evidence=ECO:0000250\|UniProtKB:Q8N2W9	20..24
		PINIT	116..254	CDD:291022	30/164 (18%)
		zf-MIZ	307..356	CDD:280964	20/48 (42%)
		Required for nuclear localization. /evidence=ECO:0000269\|PubMed:22345667	374..505		28/145 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	395..505		23/123 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3884
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.840