DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tna and pias4b

DIOPT Version :9

Sequence 1:	NP_001368945.1	Gene:	tna / 39217	FlyBaseID:	FBgn0026160	Length:	1186	Species:	Drosophila melanogaster
Sequence 2:	NP_956637.2	Gene:	pias4b / 393314	ZFINID:	ZDB-GENE-040426-1298	Length:	485	Species:	Danio rerio

Alignment Length:	331	Identity:	84/331 - (25%)
Similarity:	136/331 - (41%)	Gaps:	49/331 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   595 VSPNPDIKPPMDNSEEMRLTFPVRDGIILAPFRLLHN----LSVSNHVFHLKQN----VYNTLMC 651
            :||.....|.....:.::|.|......|:.|..|:..    :..|:.:|||.::    :.|:
Zfish   114 LSPGGTPSPKSAGPQMIKLPFYQMLETIIPPTPLVPTYGGAMQNSDFLFHLSESQQALIQNS--- 175

  Fly   652 RNDLELQLK---CFHQDDRQMNTNWPHTVTVSANATPLNIERS-EKNSTALRPLYLKAVCQPGRN 712
            |:...:|:.   |:.:........:|..:.||.|.....::.: ..|...|.|   ...|:|...
Zfish   176 RSSQPVQVVLRICYSESIGVEEDQYPPNICVSVNHNNCPVQCTYSSNKLGLEP---SRPCRPIDI 237

  Fly   713 TLQLTAS----------SCCCSHLFVLQLVHRPSVRQVLQTLHKRNLLPLEHSVQKIKRNL-SQP 766
            |..|..|          :...|:...:.||...|.:|:|..|...::...:....::...| |.|
Zfish   238 TSDLYLSFTNRFTVLWGNFGKSYSVAVYLVRLVSCQQLLDQLRSSSVEQQDVCRLRVSEKLRSDP 302

  Fly   767 EANAGPDATPQQQQQQGGGQQCAKISLKCPITKSRIRLPARGHECKHVQCFDLEAYLMINSERGS 831
            |...   ||...|           :||.||:.|.|:.:|.|...|.|:||||...||.:|.::..
Zfish   303 ETEV---ATTGLQ-----------VSLICPLVKLRMSVPCRSRGCAHLQCFDASFYLQMNEKKPR 353

  Fly   832 WRCPECSKSAITDTLEIDQYIWAILNTLGNSDVDEVIIDSSANWRALQH-----NGGMPNAPPPS 891
            |.||.|.:.|..|.|.||..:..:|.:.| .||:|:...|.:.|:|::|     |.|....|...
Zfish   354 WSCPVCHRYAPFDELRIDSLLRDVLESSG-EDVEEIKYLSDSTWKAVKHDKSNQNKGSALHPVKH 417

  Fly   892 NVPSNP 897
            ||.|.|
Zfish   418 NVNSKP 423

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tna	NP_001368945.1	Med15	216..>604	CDD:312941	2/8 (25%)
tna	NP_001368945.1	SP-RING_ZMIZ	792..839	CDD:319705	21/46 (46%)
pias4b	NP_956637.2	SAP	42..76	CDD:128789
		PINIT	131..260	CDD:291022	25/134 (19%)
		zf-MIZ	313..360	CDD:280964	20/46 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810