DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tna and Pias4

DIOPT Version :9

Sequence 1:	NP_001368945.1	Gene:	tna / 39217	FlyBaseID:	FBgn0026160	Length:	1186	Species:	Drosophila melanogaster
Sequence 2:	NP_001094227.1	Gene:	Pias4 / 362827	RGDID:	1308737	Length:	507	Species:	Rattus norvegicus

Alignment Length:	506	Identity:	112/506 - (22%)
Similarity:	185/506 - (36%)	Gaps:	141/506 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   564 YQNQGFQQNYQHSPVPGNPTPPLT-----------PACSVP-----YVS-----PNPDIKPPMDN 607
            |:.:..:::.:..|....|..||.           |....|     |::     |...:||
  Rat    62 YETRYAKKSAEPGPQAPRPLDPLALHSMPRTPLSGPTVDYPVLYGKYLNGLGRLPTKALKP---- 122

  Fly   608 SEEMRLT----FPVRDGIILAPFRLL----HNLSVSNHVFHLKQNVYNTLMCRNDLELQ------ 658
              |:||.    |.:.|. :|.|..|:    ..|..|..:|.|...  ...|.||..|||
  Rat   123 --EVRLVKLPFFNMLDE-LLKPTELVPQSAEKLQESPCIFALTPR--QVEMIRNSRELQPGVKAV 182

  Fly   659 ---LK-CFHQDDRQMNTNWPHTVTVSANATPLNIE-RSEKNSTALRPLYLKAVCQP--------- 709
               |: |:..........:|..:.|..|.:..::. ....|...:.|   |..|:|
  Rat   183 QVVLRICYSDTSCPQEDQYPPNIAVKVNHSYCSVPGYYPSNKPGVEP---KRPCRPINLTHLMYL 244

  Fly   710 --GRNTLQLTASSCCCSHLFVLQLVHRPSVRQVLQTLHKRNLLPLEHSVQKIKRNLSQPEANAGP 772
              ..|.:.:|..:...|:...|.||.:.:...:||.|   ..:.::|  .::.:.|.:.:....|
  Rat   245 SSATNRITVTWGNYGKSYSVALYLVRQLTSSDLLQRL---KTIGVKH--PELCKALVKEKLRLDP 304

  Fly   773 DATPQQQQQQGGGQQCAKISLKCPITKSRIRLPARGHECKHVQCFDLEAYLMINSERGSWRCPEC 837
            |:   :....|     .::||.||:.|.|:.:|.|...|.|:||||...||.:|.::.:|.||.|
  Rat   305 DS---EIATTG-----VRVSLICPLVKMRLSVPCRAETCAHLQCFDAVFYLQMNEKKPTWMCPVC 361

  Fly   838 SKSAITDTLEIDQYIWAILNTLGNSDVDEVIIDSSANWRALQHNGGMPNAPPPSNVPSNPSGGSG 902
            .|.|..|.|.||..:..||:..  .|.||:...:..:||.::..      ..||..|..|....|
  Rat   362 DKPAAYDQLIIDGLLSKILSEC--EDADEIEFLAEGSWRPIRAE------KEPSCSPQGPILVLG 418

  Fly   903 SNSGNGSVNPTLPVIKQELCDDIAKVMSPGSTQLPTWDSAQAMSPYNMHDMNSIASGNMMGNGGN 967
            ::..||                    ::|.|:           :|       .:.|| :.|.||
  Rat   419 TSDANG--------------------LAPASS-----------TP-------GMGSG-LSGPGG- 443

  Fly   968 TNQHGNRSSYDGFSGNHSDGSGGLPGGDGGVN----SLDQLNAMEKSLSDQ 1014
                         :|..:..:|||..|..|.:    :||..::.|....|:
  Rat   444 -------------AGGGAGAAGGLENGKTGADVVDLTLDSSSSSEDEDEDE 481

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tna	NP_001368945.1	Med15	216..>604	CDD:312941	10/60 (17%)
tna	NP_001368945.1	SP-RING_ZMIZ	792..839	CDD:319705	21/46 (46%)
Pias4	NP_001094227.1	SAP	12..46	CDD:128789
		PINIT	124..262	CDD:291022	29/143 (20%)
		zf-MIZ	315..364	CDD:280964	21/48 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810