DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tna and Zmiz2

DIOPT Version :9

Sequence 1:	NP_001368945.1	Gene:	tna / 39217	FlyBaseID:	FBgn0026160	Length:	1186	Species:	Drosophila melanogaster
Sequence 2:	NP_001093977.1	Gene:	Zmiz2 / 289783	RGDID:	1309256	Length:	920	Species:	Rattus norvegicus

Alignment Length:	1032	Identity:	350/1032 - (33%)
Similarity:	458/1032 - (44%)	Gaps:	253/1032 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   242 QQQHMGSMDAMGGYSQMGGGMHPGPNSGMMGNMNGQ------YMNGGSGQGGY--NGAQGMGMGY 298
            |.|.:|:.....| |..||.|.||...|.....:.|      :..||:.: ||  .|..|.| ||
  Rat    53 QSQVLGNPMGPAG-SPPGGSMMPGVAGGSSALTSPQCLGQQAFAEGGASK-GYVQQGVYGRG-GY 114

  Fly   299 GGGGSMGPQRHHQMTPMNQMQNMSMGPGVGGSGGMGGGMNPLQQQAAQQQMGGMNPMAKMQGMAN 363
            .||.|..|..                  .||.||:|     |...||:... .....|....||.
  Rat   115 PGGSSFTPGY------------------AGGPGGLG-----LPTHAARPST-DFTQAAAAAAMAA 155

  Fly   364 GGYPQQAPPSLTQQQQQQQQRRMAPYPHPQMHMAQKRAAAGVGGAGGMYPGNPMQQQQAQMYGNQ 428
            ......|..:.|....|::|             :|:.:..|..|.|             |.:.:|
  Rat   156 AAATATATATATVAALQEKQ-------------SQELSQYGAMGTG-------------QSFNSQ 194

  Fly   429 QMHPGS--GGGVPLPMQAGGAGNGYGRSGPMGVGNGGYGRMSAGNGMGPTGGPVMGPMGPGGMTA 491
            .:..|.  |..||..|...|.|   |..||.|:         :...|.||....|.|:..|....
  Rat   195 FLQHGGPRGPSVPPGMNPSGMG---GMMGPSGL---------SSMAMNPTRAAGMTPLYAGQRLP 247

  Fly   492 GGMGPGPGCMSQQRFMPQGS-----------GGGMPGVGYGGVGGAASHQGQFYPGSGQSAG--- 542
            ....|||         |||.           ....||..|...|..|:...|:.||.||..|
  Rat   248 QHGYPGP---------PQGQPLPRQGVKRAYSEVYPGQQYLQGGQYAASTAQYAPGPGQPPGPAS 303

  Fly   543 --------MQQAGGMCPAGPGAVATTGNP---YQNQGFQQN--------------------YQHS 576
                    :||......:.||.......|   :..||...|                    |..|
  Rat   304 SYAGHRLPLQQGMAQSLSAPGPTGLHYKPTEQFNGQGASFNGGSISYSQPGLSGPSRSIPAYPSS 368

  Fly   577 PVPGNPTPPLTPACSVPYVSPN--------PDIKPPMDN----------SEEMRLTFPVRDGIIL 623
            |:|||||||:||:.|.||:||:        ||:||.:.:          .:|:|||||||||::|
  Rat   369 PLPGNPTPPMTPSSSAPYMSPSQEVKSPFLPDLKPGLSSLHPSPSGSVPCDELRLTFPVRDGVVL 433

  Fly   624 APFRLLHNLSVSNHVFHLKQNVYNTLMCRNDLELQLKCFHQDDRQMNTNWPHTVTVSANATPLNI 688
            .||||.|||:||||||.|:.:||.|||.|.|||||.||:|.:|||||||||.:|.||.|||||:|
  Rat   434 EPFRLQHNLAVSNHVFQLRDSVYKTLMLRPDLELQFKCYHHEDRQMNTNWPASVQVSVNATPLSI 498

  Fly   689 ERSEKNSTALRPLYLKAVCQPGRNTLQLTASSCCCSHLFVLQLVHRPSVRQVLQTLHKRNLLPLE 753
            ||.: |.|:.:|||||.||||||||:|:|.::||||||||||||||||||.|||.|.|:.|||.|
  Rat   499 ERGD-NKTSHKPLYLKHVCQPGRNTIQITVTACCCSHLFVLQLVHRPSVRSVLQGLLKKRLLPAE 562

  Fly   754 HSVQKIKRNLSQPEANAGPDATPQQQQQQGGGQQCAKISLKCPITKSRIRLPARGHECKHVQCFD 818
            |.:.|||||.|    :.....||....:.|..|...|:|||||||..||:||||||:|:|:||||
  Rat   563 HCITKIKRNFS----SGTIPGTPGPNGEDGVEQTAIKVSLKCPITFRRIQLPARGHDCRHIQCFD 623

  Fly   819 LEAYLMINSERGSWRCPECSKSAITDTLEIDQYIWAILNTLGNSDVDEVIIDSSANWRALQHNGG 883
            ||:||.:|.|||:||||.|:|:|:.:.||:|||:..||..:.|||.:|:.||.:.:|:.:.
  Rat   624 LESYLQLNCERGTWRCPVCNKTALLEGLEVDQYMLGILIYIQNSDYEEITIDPTCSWKPVP---- 684

  Fly   884 MPNAPPPSNVPSNPSGGSGSNSGNGSVNPTLPVIKQELCDDIAKVMSPGSTQLPTWDSAQAMSPY 948
               ..|..::...|.|               ||:|:      .:.:||....:|:
  Rat   685 ---VKPDLHIKEEPDG---------------PVLKR------CRTVSPAHVLMPS---------- 715

  Fly   949 NMHDMNSIASGNMMGNGGNTNQHGNRSSYDGFSGNHSDGSGGL-PGGDGGVNSLDQLNAMEKSLS 1012
               .|..||:   :|.|..........|....|...|.||..| ||                :..
  Rat   716 ---VMEMIAA---LGPGAAPFAPLQPPSAPTPSDYPSQGSNFLGPG----------------TFP 758

  Fly  1013 DQMPH-TPHTPGAASHPMTPGGPPSVSSSHNEPISGGTPNANGSGSATNGSGNNNSSTGHNSP-Q 1075
            :..|. ||.||..|....   |||.:|...:.|.|..||:.  |.....|   ..:..||..| .
  Rat   759 ESFPSATPATPNLAEFTQ---GPPPISYQSDIPSSLLTPDK--SAPCLPG---QMAPAGHLDPAH 815

  Fly  1076 TPGTPSRMGGGMGGSGSADSQQQQQEQLLNSLMSSQTQLKFSESDLSAELQSFDAA--------- 1131
            .||.|......:|.:........      |...:|:..|....:...:|| :|:.|
  Rat   816 NPGPPGLHTPNLGPTPGTQLHHP------NPSPASRQPLGQPNTGPISEL-AFNPATGMMGPPSM 873

  Fly  1132 --AAAINDTAHDLNLLQDVDPMEILSYLDPQPDLNTPPSSGSSNNNASDDLLATLFD 1186
              |...::.|.|| |.:..:|.|:||||.| |||.|         |:||||| :||:
  Rat   874 TGAGEASEPALDL-LPELTNPDELLSYLGP-PDLPT---------NSSDDLL-SLFE 918

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tna	NP_001368945.1	Med15	216..>604	CDD:312941	108/424 (25%)
tna	NP_001368945.1	SP-RING_ZMIZ	792..839	CDD:319705	34/46 (74%)
Zmiz2	NP_001093977.1	SP-RING_ZMIZ	597..644	CDD:319705	34/46 (74%)
Zmiz2	NP_001093977.1	PHA03378	<683..886	CDD:223065	54/277 (19%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	303	1.000	Domainoid score	I1344
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	420	1.000	Inparanoid score	I1735
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D143293at33208
OrthoFinder	1	1.000	-	-		FOG0002880
OrthoInspector	1	1.000	-	-		otm46331
orthoMCL	1	0.900	-	-		OOG6_105005
Panther	1	1.100	-	-	LDO	PTHR10782
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2238
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.970