DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tna and pli1

DIOPT Version :9

Sequence 1:	NP_001368945.1	Gene:	tna / 39217	FlyBaseID:	FBgn0026160	Length:	1186	Species:	Drosophila melanogaster
Sequence 2:	NP_593123.1	Gene:	pli1 / 2541580	PomBaseID:	SPAC1687.05	Length:	727	Species:	Schizosaccharomyces pombe

Alignment Length:	577	Identity:	127/577 - (22%)
Similarity:	212/577 - (36%)	Gaps:	136/577 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   664 QDDRQMNTNWPHTVTVSANATPLNIERSEKNSTALRPLYLKAVCQPGRNTLQLTASSCCCSHLFV 728
            |.:.::|....|     ||...|..:....|...:..|..|....||.|.:....:| ..|:..|
pombe   196 QMELRINNQVAH-----ANYRRLKGKPGTTNPADITDLVSKYAGPPGNNVVIYYMNS-TKSYSVV 254

  Fly   729 LQLVHRPSVRQVLQTLHKRNLLPLEHSVQKIKRNLSQPEANAGPDATPQQQQQQGGGQQCAKISL 793
            :..|...::..::..:..|.....|..:::||.:....:..|                ....|||
pombe   255 VCFVKVYTIENLVDQIKSRKAESKEKIIERIKNDNQDADIIA----------------TSTDISL 303

  Fly   794 KCPITKSRIRLPARGHECKHVQCFDLEAYLMINSERGSWRCPECSKSAITDTLEIDQYIWAIL-N 857
            |||::.|||.||.|...|||:||||..|:|.:|.:..||.||.|:.......|.||.::..|| :
pombe   304 KCPLSFSRISLPVRSVFCKHIQCFDASAFLEMNKQTPSWMCPVCASHIQFSDLIIDGFMQHILES 368

  Fly   858 TLGNSDVDEVIIDSSANWRALQHNGGMPNAPP---PSNVPSNPSGGSG----SNSGN------GS 909
            |..||:.  :.:|...||:....:..:.::..   |.......|.|.|    :|..|      .|
pombe   369 TPSNSET--ITVDPEGNWKLNTFDEPVESSEDEFVPKEKVIELSDGEGISTMANKSNDQPTRRAS 431

  Fly   910 VNPTLP---------VIKQELCDDIAKVM-----SPGSTQLPTWDSAQAMSPYNMHDMNSIASGN 960
            .:.:.|         ||...:.||...|.     ||.:.......|....|| |:....|..|.|
pombe   432 THNSGPPAKRKRESLVIDLTISDDDENVATSTTESPSNATKENSLSRNVQSP-NIDTAISNRSTN 495

  Fly   961 MM-GNGG---------------NTNQHGNRSSYDGFSGNHSDGSGGL--PGGDGGVNSLDQLNAM 1007
            :. |:.|               :|::....|.:.|::|.....||.|  |......||..|.:.
pombe   496 VRHGHPGFKDYTVENSPASRERSTSESAQSSVHMGYAGEGGLLSGALRAPSQQNNNNSNTQHSI- 559

  Fly  1008 EKSLSDQMPHTPHTPGAASHPMTPGGPPSVSSSHNEPISGGT---------------PNANGSGS 1057
              :|...:| :|:.|..:..|.|.....|:..|:....|..:               .|...:.:
pombe   560 --NLHTIVP-SPYEPPLSVTPSTAITNLSIPESNRTNSSASSKSFTMNDLILPPLHLKNTTQTNN 621

  Fly  1058 ATNGSGNNNSSTGHN-----SPQTPG-TPSRMGGGMGGSGSADSQQQQQEQLLNSL--------- 1107
            |...:.::|.|..|:     .||.|. ...:...|:        .:.:.||.::::
pombe   622 AHEDAQSSNLSQNHSLFYERIPQRPSYRIEKQNKGI--------YEDENEQSISAMPIPRAHPQL 678

  Fly  1108 ---MSSQT------QLKFSESDLSAELQSFDAAAAAINDTAHDL------NLLQDVD 1149
               :.|||      :.:.::.|.::||||        |::.|:.      |..|.:|
pombe   679 PKNLLSQTAGPLWDEQQDAQVDWNSELQS--------NNSYHNSGFEGTGNTFQSID 727

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tna	NP_001368945.1	Med15	216..>604	CDD:312941
tna	NP_001368945.1	SP-RING_ZMIZ	792..839	CDD:319705	26/46 (57%)
pli1	NP_593123.1	SAP	21..52	CDD:280251
		PINIT	119..251	CDD:291022	13/60 (22%)
		zf-MIZ	301..347	CDD:280964	26/45 (58%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	66	1.000	Domainoid score	I2790
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR10782
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3884
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.030