DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tna and Pias2

DIOPT Version :9

Sequence 1:	NP_001368945.1	Gene:	tna / 39217	FlyBaseID:	FBgn0026160	Length:	1186	Species:	Drosophila melanogaster
Sequence 2:	XP_006526486.1	Gene:	Pias2 / 17344	MGIID:	1096566	Length:	622	Species:	Mus musculus

Alignment Length:	580	Identity:	125/580 - (21%)
Similarity:	215/580 - (37%)	Gaps:	145/580 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   575 HSPVPGNPTPPLTPACSVPYV------------SPNPDIKPPMDNSEEMRLTFPVRD--GIILAP 625
            || :|.....|.:|:..|..|            .|:|.| ||:....::: ..|..|  .:::.|
Mouse   102 HS-LPSTSITPHSPSSPVGSVLLQDTKPTFEMQQPSPPI-PPVHPDVQLK-NLPFYDVLDVLIKP 163

  Fly   626 FRLLHNLSVSN-----HVFHL-KQNVYNTLMCRNDL---------ELQLK-CFHQDDRQMNTNWP 674
            ..|:.: |:..     .:|.| .|.|....:.|:.|         ::||: |..:.......|:|
Mouse   164 TSLVQS-SIQRFQEKFFIFALTPQQVREICISRDFLPGGRRDYTVQVQLRLCLAETSCPQEDNYP 227

  Fly   675 HTVTVSAN----------------------ATPLNIERSEKNSTALRPLYLKAVCQPGRNTLQLT 717
            :::.:..|                      ..||||....:.|:|:            .|.:.::
Mouse   228 NSLCIKVNGKLFPLPGYAPPPKNGIEQKRPGRPLNITSLVRLSSAV------------PNQISIS 280

  Fly   718 -ASSCCCSHLFVLQLVHRPSVRQVLQTLHKRNLLPLEHSVQKIKRNLSQPEANAGPD---ATPQQ 778
             ||....::...:.||.:.:...:||.|..:.:...:||...||..|:     |.||   ||..
Mouse   281 WASEIGKNYSMSVYLVRQLTSAMLLQRLKMKGIRNPDHSRALIKEKLT-----ADPDSEIATTS- 339

  Fly   779 QQQQGGGQQCAKISLKCPITKSRIRLPARGHECKHVQCFDLEAYLMINSERGSWRCPECSKSAIT 843
                      .::||.||:.|.|:.:|.|...|.|:||||...||.:|.::.:|.||.|.|.|..
Mouse   340 ----------LRVSLMCPLGKMRLTIPCRAVTCTHLQCFDAALYLQMNEKKPTWICPVCDKKAAY 394

  Fly   844 DTLEIDQYIWAILNTLGNSDVDEVIIDSSANWRALQHNGGMPNAPPPSNVPSNPSGGSGSNSGNG 908
            ::|.:|.....|||..  |||||:......:|..::..   ..|...::.|......|...|...
Mouse   395 ESLILDGLFMEILNDC--SDVDEIKFQEDGSWCPMRPK---KEAMKVTSQPCTKVESSSVFSKPC 454

  Fly   909 SVNPTLPVIKQELCDDIAKVMSPGSTQLPTWDSAQAMSPYNMHDMNSIASGNMMGNGGNTNQHGN 973
            ||.......|:::  |:..:....|:.......|:....:.....:|...|.:|
Mouse   455 SVTVASDASKKKI--DVIDLTIESSSDEEEDPPAKRKCIFMSETQSSPTKGVLM----------- 506

  Fly   974 RSSYDGFSGNHSDGSGGLPGGDGGVNSLDQLNAMEKSLSDQMPHTPHTPGAASHPMTPG------ 1032
                      :...|..:|    .|.|:|.. |:..||:|......|||.::.....||
Mouse   507 ----------YQPSSVRVP----SVTSVDPA-AIPPSLTDYSVPFHHTPVSSMSSDLPGLDFLSL 556

  Fly  1033 --------GPPSVSSSHNEPISGGTPNANGSG---SATNGSGNNN-------SSTGHNSP 1074
                    .||....|...|::..:.:...:.   |:|:.|.:::       :|:|.|.|
Mouse   557 IPVDPQQYCPPMFLDSLTSPLTASSTSVTTTSPHESSTHVSSSSSRSETGVITSSGRNIP 616

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tna	NP_001368945.1	Med15	216..>604	CDD:312941	10/40 (25%)
tna	NP_001368945.1	SP-RING_ZMIZ	792..839	CDD:319705	21/46 (46%)
Pias2	XP_006526486.1	SAP	11..45	CDD:128789
		PINIT	147..291	CDD:373014	26/157 (17%)
		SP-RING_PIAS	343..390	CDD:319704	21/46 (46%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2169
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3884
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840