Protein Alignment tna and gei-17

DIOPT Version :10

• Sequence 1: NP_001368945.1
• Gene: tna / 39217
• FlyBaseID: FBgn0026160
• Length: 1186
• Species: Drosophila melanogaster
• Sequence 2: NP_492444.4
• Gene: gei-17 / 172733
• WormBaseID: WBGene00001574
• Length: 780
• Species: Caenorhabditis elegans
• Alignment Length: 910
• Identity: 185/910 - (20%)
• Similarity: 270/910 - (29%)
• Gaps: 392/910 - (43%)

  Fly   363 NGGYPQQAPPSLTQQQQQQQQRRMAPYPHPQMHMAQKRAAAGVGGAGGMYPGNPMQQQQAQMYGN 427
            ||.|..|..|:.|.|.      |..||..|..           .||......:..||||.|.
 Worm    80 NGNYEMQKRPATTSQV------RSHPYVLPSR-----------SGASNHLVNHHYQQQQQQQ--- 124

  Fly   428 QQMHPGSGGGVPLPMQAGGAGNGYGRSGPMGVGNGGYGRMSAGNGMGPTGGPVMGPMGPGGMTAG 492
                                                                             
 Worm   125 ----------------------------------------------------------------- 124

  Fly   493 GMGPGPGCMSQQRFMPQGSGGGMPGVGYGGVGGAASH----QGQFYPG-----SGQSAGMQQAGG 548
               |.|..:..|:.|                   |||    |.|.:|.     :.:....|..|.
 Worm   125 ---PQPHNLLHQQMM-------------------ASHHSHLQQQHHPSTVRWLTPELLEEQLRGS 167

  Fly   549 MCPAGPGAVATTGNP----YQNQG--FQQNYQHSPVPGNPTPPLTPACSVPYVSPNPDIKPPMDN 607
            |....|.|.|.|..|    :.|.|  .||:.|.|.....|.                  |...||
 Worm   168 MRYGAPAAAAATNAPLHSSFPNHGRSSQQSLQKSEKSNRPK------------------KMYADN 214

  Fly   608 SEEMRLTFPVRDGIILAPFRLLHN----------------LSVSNHVFHLKQNVYNTLMCRNDLE 656
            .|.:.|.|.....::|.|.. ||:                |..:.|:..:......|.:.|  .|
 Worm   215 FEPLPLPFYDVISVLLKPVE-LHSSDSPTLKQTKQLQFPFLLTAEHISKISYRADVTPLPR--YE 276

  Fly   657 LQLKCFH---------QDDRQMN---------TNWPHTV-TVSANATP----------LNIERSE 692
            |||:.|:         :||..:|         ...|:.: |...||.|          .|:.|.:
 Worm   277 LQLRFFNLTEPVQGPQKDDFPLNCYARVDDSVVQLPNVIPTNKTNAEPKRPSRPVNITSNMNRYK 341

  Fly   693 KNST-ALRPLYLKAVCQPGRNTLQLTASSCCCSHLFVLQLVHRPS----VRQVLQTLHKRNLLPL 752
            |..| |:..|..|.|...|                  :..|||.:    .:::.|.:.:..  .|
 Worm   342 KEHTVAVEWLADKRVWAAG------------------VYFVHRVNSDILFKRLNQNVSRHR--SL 386

  Fly   753 EHSVQKIKRNLSQPEANAGPDATPQQQQQQGGGQQCAKISLKCPITKSRIRLPARGHECKHVQCF 817
            |.:.|::.:.||..|.:...|.              ..|||..|:.|:|:..|:|..:|.|:|||
 Worm   387 EVTKQEVIKKLSGGEDDIAMDR--------------LNISLLDPLCKTRMTTPSRCQDCTHLQCF 437

  Fly   818 DLEAYLMINSERGSWRCPECSKSAITDTLEIDQYIWAIL-----NT------------------- 858
            ||.:|||:|.::.:|:||.||.:...|.|.:|.|...:|     ||
 Worm   438 DLLSYLMMNEKKPTWQCPVCSSNCPYDRLIVDDYFLDMLAKVDKNTTEVELKEDGSYDVIKEEAF 502

  Fly   859 -LGNSDVDEVIIDSSANWRALQHNGGMPNAPPPSNVPSNPSGGSGSNSGNGSVNPTLPVIKQELC 922
             :.:.|.|:|:                     |:.|  |.:....|.:|||..|....  |:...
 Worm   503 CISDDDDDDVV---------------------PATV--NGTASCSSTNGNGLANEAAK--KKPAD 542

  Fly   923 DDIAKVMSPGSTQLPTWDSAQAMSPYNMHDMNSIASGNMMGNGGNTNQHGNRSSYDGFS-GNHSD 986
            |||..:......:|            |...|||:                    .|.|| |.|:.
 Worm   543 DDIITLSDDDDEEL------------NRGIMNSL--------------------NDSFSPGRHTA 575

  Fly   987 GSGGLPGGDGGVNSLDQLNAM-------EKSLSDQ-----MPHTPHTPGAASHPMTPGGPPSVSS 1039
            .:              :|.|.       :|:..|.     :..||..|.|||..:    |....|
 Worm   576 SA--------------ELAAQKTPPQQKKKTKDDDIEIITLDDTPPRPVAASANL----PMRQMS 622

  Fly  1040 SHNEPISGGTPNANGSGSATNGSGNNNSSTGHNSPQTPGTPSRMGGGMGGSGS-ADSQQQQQEQL 1103
            ..|:...|.:|    ||.|:                     ::||...|.|.: .|:..:..||.
 Worm   623 QQNQMPVGSSP----SGMAS---------------------TQMGMNEGASKTIRDALNKIGEQS 662

  Fly  1104 LNSLMSSQTQLKFSESDLSAELQSFDAAAAAINDTAHDLNLLQDVDPMEILSYLDPQPDLNTPPS 1168
            .||...|...::                   ::.|.|.||..|.       ||::|.....||.|
 Worm   663 ANSSTQSSPLVQ-------------------LHHTTHPLNFAQS-------SYMNPSSGSQTPTS 701

  Fly  1169  1168
             Worm   702  701

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
tna	NP_001368945.1	Med15	216..>604	CDD:312941	44/255 (17%)
		SP-RING_ZMIZ	792..839	CDD:438445	22/46 (48%)
gei-17	NP_492444.4	PINIT	219..365	CDD:464136	32/166 (19%)
		SP-RING_PIAS-like	412..458	CDD:438312	21/45 (47%)