DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment tna and PIAS3

DIOPT Version :10

Sequence 1:NP_001368945.1 Gene:tna / 39217 FlyBaseID:FBgn0026160 Length:1186 Species:Drosophila melanogaster
Sequence 2:NP_006090.2 Gene:PIAS3 / 10401 HGNCID:16861 Length:628 Species:Homo sapiens


Alignment Length:617 Identity:137/617 - (22%)
Similarity:209/617 - (33%) Gaps:190/617 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   576 SPVPGNPTP--PLTPACSVPYVSPNP----DIKPPMDNSEEMRLTFPVRDGIILAP---FRLLHN 631
            ||| |:|.|  |:.|....|.....|    |:.||:..        ||...:.:.|   :.:...
Human    85 SPV-GSPGPLAPIPPTLLAPGTLLGPKREVDMHPPLPQ--------PVHPDVTMKPLPFYEVYGE 140

  Fly   632 L-------SVSNHVFH--------LKQNVYNTL---------MCRNDLELQLK-CFHQDDRQMNT 671
            |       |.|:..|.        ..|.|...|         .|...:::||: |..:.......
Human   141 LIRPTTLASTSSQRFEEAHFTFALTPQQVQQILTSREVLPGAKCDYTIQVQLRFCLCETSCPQED 205

  Fly   672 NWPHTVTVSAN----------------------ATPLNI-ERSEKNSTALRPLYLKAVCQPGRNT 713
            .:|..:.|..|                      :.|:|| ..:..::|....:.:....:.||| 
Human   206 YFPPNLFVKVNGKLCPLPGYLPPTKNGAEPKRPSRPINITPLARLSATVPNTIVVNWSSEFGRN- 269

  Fly   714 LQLTASSCCCSHLFVLQLVHRPSVRQVLQTLHKRNLLPLEHSVQKIKRNLSQPEANAGPD---AT 775
                       :...:.||.:.:...:||.|..:.:...:||...||..|:     |.||   ||
Human   270 -----------YSLSVYLVRQLTAGTLLQKLRAKGIRNPDHSRALIKEKLT-----ADPDSEVAT 318

  Fly   776 PQQQQQQGGGQQCAKISLKCPITKSRIRLPARGHECKHVQCFDLEAYLMINSERGSWRCPECSKS 840
            ..           .::||.||:.|.|:.:|.|...|.|:|.||...||.:|.::.:|.||.|.|.
Human   319 TS-----------LRVSLMCPLGKMRLTVPCRALTCAHLQSFDAALYLQMNEKKPTWTCPVCDKK 372

  Fly   841 AITDTLEIDQYIWAILNTLGNSDVDEVIIDSSANWRALQHNGGMPN------APPP----SNVPS 895
            |..::|.||.....||::.  ||.||:......:|..::     |.      .|||    ..:..
Human   373 APYESLIIDGLFMEILSSC--SDCDEIQFMEDGSWCPMK-----PKKEASEVCPPPGYGLDGLQY 430

  Fly   896 NP-SGGSGSNS-----------GNGSVNPTLPVIKQELCDDIAKVMS-PGSTQLPTWDSAQAMSP 947
            :| .||..|.:           .:.|....||..|:......|.:.: |||..:.|         
Human   431 SPVQGGDPSENKKKVEVIDLTIESSSDEEDLPPTKKHCSVTSAAIPALPGSKGVLT--------- 486

  Fly   948 YNMHDMNSIASGNMMGNGGNTNQHGNRSSYDGFSGNHSDGSGGLP----------GGDGGVNSLD 1002
             :.|..:|:.....||..|                  .|....||          |.|  :..||
Human   487 -SGHQPSSVLRSPAMGTLG------------------GDFLSSLPLHEYPPAFPLGAD--IQGLD 530

  Fly  1003 QLNAME-----------KSLSDQ--MPHTPHTPGAASHPMTPGGP--PSVSSSHNEPISGGTPNA 1052
            ..:.::           .||.:|  :.|.....|..||.:   ||  |::.|||........|..
Human   531 LFSFLQTESQHYGPSVITSLDEQDALGHFFQYRGTPSHFL---GPLAPTLGSSHCSATPAPPPGR 592

  Fly  1053 NGSGSATNGSGNNNSSTGHNSPQTPGTPSRMG 1084
            ..|..|..|:    ...||..| .|..||..|
Human   593 VSSIVAPGGA----LREGHGGP-LPSGPSLTG 619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
tnaNP_001368945.1 Med15 216..>604 CDD:312941 11/33 (33%)
SP-RING_ZMIZ 792..839 CDD:438445 20/46 (43%)
PIAS3NP_006090.2 Interaction with CCAR2. /evidence=ECO:0000269|PubMed:25406032 1..200 27/123 (22%)
SAP 11..>36 CDD:128789
LXXLL motif 19..23
PINIT 130..278 CDD:464136 23/159 (14%)
SP-RING_PIAS3 319..380 CDD:438469 23/71 (32%)
SUMO1-binding. /evidence=ECO:0000250 450..460 1/9 (11%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 597..617 7/24 (29%)
Blue background indicates that the domain is not in the aligned region.

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