DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment tna and pias3

DIOPT Version :9

Sequence 1:	NP_001368945.1	Gene:	tna / 39217	FlyBaseID:	FBgn0026160	Length:	1186	Species:	Drosophila melanogaster
Sequence 2:	NP_001116890.1	Gene:	pias3 / 100144644	XenbaseID:	XB-GENE-486632	Length:	635	Species:	Xenopus tropicalis

Alignment Length:	686	Identity:	157/686 - (22%)
Similarity:	234/686 - (34%)	Gaps:	202/686 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   498 PGC----------MSQQRF-----------MPQGSGGGMPGVGYGGVGGAASHQGQFYPGSGQSA 541
            |||          :.::||           |....||.:|... ....||..|.|  |..|..|.
Frog    38 PGCSPAIQMKIKELYRRRFPRKVISSTDLTMLHMQGGALPSAN-SLAQGAVCHMG--YDTSASSP 99

  Fly   542 GMQQAGGMCP----AGPGAVATTGNPYQNQGFQQNYQHSPVPGNPTPPLTPACSVPYVSPNPDIK 602
            .:  :..|.|    .||                   :|.....:.|||:.|.        :||:|
Frog   100 TV--SSSMLPPVPMLGP-------------------KHETDLSHLTPPIHPV--------HPDVK 135

  Fly   603 PPMDNSEEMRLTF-PVRDGIILAPFRLLHNLSVSNHVFHLK-----QNVYNTLMCRNDL------ 655
                   ..||.| .|.|.:| .|..|....|......|..     |.|:..|..|:.|
Frog   136 -------MKRLPFYDVYDELI-KPTTLASTNSQRFEEAHFNFALTPQQVHQILSSRDILPGAKCD 192

  Fly   656 ---ELQLK-CFHQDDRQMNTNWPHTVTVSANA----------------------TPLNIERSEK- 693
               ::||: |..:........:|..:.|..|.                      .|:||....:
Frog   193 YTVQVQLRFCLCETSCPQEDYFPPNLFVKVNQKLCPLPGYLPPTKNGAEPKRPNRPINITPLIRL 257

  Fly   694 NSTALRPLYLKAVCQPGRNTLQLTASSCCCSHLFVLQLVHRPSVRQVLQTLHKRNLLPLEHSVQK 758
            .||....:.:....:.|||            :...:.||.:.:...:||.|..:.:...:||...
Frog   258 TSTVPNTIVVNWSSEFGRN------------YSLSVYLVKQLTSVTLLQKLRAKGIRNPDHSRAL 310

  Fly   759 IKRNLSQPEANAGPD---ATPQQQQQQGGGQQCAKISLKCPITKSRIRLPARGHECKHVQCFDLE 820
            ||..|:     |.||   ||..           .::||.||:.|.|:.:|.|...|.|:||||..
Frog   311 IKEKLT-----ADPDSEIATTS-----------LRVSLMCPLGKMRLTVPCRAITCTHLQCFDAA 359

  Fly   821 AYLMINSERGSWRCPECSKSAITDTLEIDQYIWAILNTLGNSDVDEVIIDSSANWRALQHNGGMP 885
            .||.:|.::.:|.||.|.|.|..|.|.||.....|||:.  :|.||:......:|..::......
Frog   360 LYLQMNEKKPTWTCPVCDKKAPYDMLIIDGLFMDILNSC--TDCDEIQFMEDGSWCPMRPKKEKQ 422

  Fly   886 NAPPPSNVPSNPSGGSGSNSGNGSVNPTL----------PVIKQELCDDIAKVMSPGSTQLPTWD 940
            :...||     |.||..: ||..|:.|.|          .||...|.....:...|...|.|...
Frog   423 DICQPS-----PYGGIEA-SGIYSMTPELKHSAEAKKKVEVIDLTLDSSSDEEEPPSKKQCPVTS 481

  Fly   941 SA--QAMSPYNM----HDMNSIASGNMMGNGGN--------TNQHGNRSSY---------DGFSG 982
            :|  .|..|..:    |..:|:.....|...|:        .:.|   .||         |.||.
Frog   482 AAIPSATGPKGVISVDHQPSSVLRSPPMATIGSDYLSSLPLPDYH---RSYPVPPDIQGLDLFSF 543

  Fly   983 NHSDGSGGLPGGDGGVNSLDQLNAMEKSLSDQMPHTPHTPGAASHPMTPGGPPSVSSSHNEPISG 1047
            ..:|.:...|   ..:.|||:.:|:......:.|     ||....|:|    .:::.||
Frog   544 LQADSTHYSP---SVITSLDEQDALSHFFQYRAP-----PGHYMSPLT----QTITGSH------ 590

  Fly  1048 GTPNANGSGSATNGSGNNNSSTGHNSPQT-----PG 1078
            .||:.....|:...:.:...|..||:.|:     ||
Frog   591 ATPSGASRISSIVSTSSLRESHSHNTSQSASSALPG 626

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
tna	NP_001368945.1	Med15	216..>604	CDD:312941	28/130 (22%)
tna	NP_001368945.1	SP-RING_ZMIZ	792..839	CDD:319705	21/46 (46%)
pias3	NP_001116890.1	SAP	2..36	CDD:128789
		PINIT	133..270	CDD:291022	28/144 (19%)
		zf-MIZ	330..378	CDD:280964	21/47 (45%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3884
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.030