DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment NijA and NINJ1

DIOPT Version :9

Sequence 1:	NP_996040.1	Gene:	NijA / 39215	FlyBaseID:	FBgn0036101	Length:	245	Species:	Drosophila melanogaster
Sequence 2:	NP_004139.2	Gene:	NINJ1 / 4814	HGNCID:	7824	Length:	152	Species:	Homo sapiens

Alignment Length:	154	Identity:	53/154 - (34%)
Similarity:	80/154 - (51%)	Gaps:	25/154 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 NGGRRPSFSFPG-----------YNGPGFVTINGVETPIPDVNAYQHKKTLAQGMMDLALLSANA 152
            |||..|  ..||           .:||    ||        ||.|..||:.|:.|:|:|||.|||
Human    11 NGGLPP--GTPGSPDASPARWGWRHGP----IN--------VNHYASKKSAAESMLDIALLMANA 61

  Fly   153 NQLRYVLETSSQHPYFYPSLLFISLSIIFQIAVGVGLILNGQYNIKNGHDICRANRINNYTVSGI 217
            :||:.|:|......::.|.::.||:|::.||.|||.||...:|::.|.....:.:.:||.....:
Human    62 SQLKAVVEQGPSFAFYVPLVVLISISLVLQIGVGVLLIFLVKYDLNNPAKHAKLDFLNNLATGLV 126

  Fly   218 FIVTVVNVLISAFTVDRDTVPALP 241
            ||:.|||:.|:||.|.:..:...|
Human   127 FIIVVVNIFITAFGVQKPLMDMAP 150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
NijA	NP_996040.1	Ninjurin	130..230	CDD:282740	38/99 (38%)
NINJ1	NP_004139.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26		6/16 (38%)
		N-terminal adhesion motif. /evidence=ECO:0000269\|PubMed:33028854	26..37		2/14 (14%)
		Ninjurin	39..139	CDD:309864	38/99 (38%)
		Required to induce plasma membrane rupture. /evidence=ECO:0000250\|UniProtKB:O70131	40..69		15/28 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_2BDMP
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1560683at2759
OrthoFinder	1	1.000	-	-		FOG0001262
OrthoInspector	1	1.000	-	-		mtm8469
orthoMCL	1	0.900	-	-		OOG6_103284
Panther	1	1.100	-	-	O	PTHR12316
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.780