DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and DLG5

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	NP_004738.3	Gene:	DLG5 / 9231	HGNCID:	2904	Length:	1919	Species:	Homo sapiens

Alignment Length:	190	Identity:	47/190 - (24%)
Similarity:	80/190 - (42%)	Gaps:	31/190 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 ALSSSS----SSSSAAASLTSKKMTAPGPRPLVLCGPSGSGKSTLLKRLFAEFPSTFGFSISHTT 71
            |.||.|    ..|.:.|....:|:.....||:::.||.   ...:.:.|..|.|..|       .
Human  1711 AFSSDSIPLFEDSVSLAYQRVQKVDCTALRPVLILGPL---LDVVKEMLVNEAPGKF-------C 1765

  Fly    72 RKPREGEEHGVHYYFVERPEMEAAIAGDE---FIETAEFTGNLYGTSKAAVREIQAQGRVCILDI 133
            |.|.|          |.:...:|...|.:   |::....:|:...|:.|:::||..:.|.|:|||
Human  1766 RCPLE----------VMKASQQAIERGVKDCLFVDYKRRSGHFDVTTVASIKEITEKNRHCLLDI 1820

  Fly   134 EQKGVEQIKRTDLNPILIF---NNPPSIKELERRLRKRGSETEESLSKRLNAAQ-VELDY 189
            ....:|::....:.||:||   .:...|||....:..|...|:....::..||| :|.:|
Human  1821 APHAIERLHHMHIYPIVIFIHYKSAKHIKEQRDPIYLRDKVTQRHSKEQFEAAQKLEQEY 1880

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	40/163 (25%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	40/161 (25%)
DLG5	NP_004738.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	98..142
		Takusan	130..212	CDD:282652
		TPR_MLP1_2	231..353	CDD:285204
		COG1340	295..587	CDD:224259
		FliJ	310..449	CDD:304890
		BAR	417..601	CDD:299863
		PDZ_signaling	620..707	CDD:238492
		DegQ	<702..771	CDD:223343
		PDZ_signaling	722..790	CDD:238492
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	927..1122
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1150..1187
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1201..1230
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1245..1264
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1271..1306
		PDZ	1347..1429	CDD:214570
		dbPDZ_assoc	1427..1499	CDD:293216
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1434..1493
		PDZ	1499..1582	CDD:214570
		SH3_DLG5	1597..1659	CDD:212794
		GuKc	1732..1908	CDD:214504	41/169 (24%)
		Guanylate_kin	1740..1907	CDD:279019	40/161 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810