DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and CARD11

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	NP_001311210.1	Gene:	CARD11 / 84433	HGNCID:	16393	Length:	1154	Species:	Homo sapiens

Alignment Length:	253	Identity:	49/253 - (19%)
Similarity:	100/253 - (39%)	Gaps:	53/253 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 RALSSSSSSSSAAASLTSKKMTAPGPRPLVLCGP-SGSGKS------TLLKRLFAE--FPSTFGF 65
            |.:|.|...|.|.:||.:.|:.......|   .| |..||:      :|::..:.|  .|..|..
Human   920 RIISGSPLGSLARSSLDATKLLTEKQEEL---DPESELGKNLSLIPYSLVRAFYCERRRPVLFTP 981

  Fly    66 SISHTTRKPREGEEHGVHYYFVERPEMEAAIAGDEFIETAEFTGNLYGTSK----------AAVR 120
            ::...|...|.....|...:.:.:.::   :..|||:...:....:|...|          |.:.
Human   982 TVLAKTLVQRLLNSGGAMEFTICKSDI---VTRDEFLRRQKTETIIYSREKNPNAFECIAPANIE 1043

  Fly   121 EIQAQGRVCILDIEQKGVEQIKRTDLNPILIFNNPPSIKELERRLRK-----RGSETEESLSKRL 180
            .:.|:.:.|:|:........:.::::.||::|     |:..|:.:::     ...||||...:..
Human  1044 AVAAKNKHCLLEAGIGCTRDLIKSNIYPIVLF-----IRVCEKNIKRFRKLLPRPETEEEFLRVC 1103

  Fly   181 NAAQVELD-----YGLTPGNFHKIINNVDIDV--AYEEFRNFVVQELKEQQKQGVSVN 231
            ...:.||:     |.           .|:.|:  :.||....|..::.|:|::.:.|:
Human  1104 RLKEKELEALPCLYA-----------TVEPDMWGSVEELLRVVKDKIGEEQRKTIWVD 1150

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	38/215 (18%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	37/210 (18%)
CARD11	NP_001311210.1	CARD_CARD11_CARMA1	22..107	CDD:260070
		Linker. /evidence=ECO:0000305\|PubMed:31296852	111..128
		BAR	<173..>257	CDD:299863
		GBP_C	<252..418	CDD:303769
		coiled coil	387..398	CDD:293879
		coiled coil	407..418	CDD:293879
		Inhibitory domain (ID). /evidence=ECO:0000303\|PubMed:31296852	450..666
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	460..626
		PDZ_signaling	680..752	CDD:238492
		SH3	777..839	CDD:302595
		NK	<1009..1143	CDD:302627	27/149 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900