DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and Lrguk

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	XP_006506776.1	Gene:	Lrguk / 74354	MGIID:	1921604	Length:	1341	Species:	Mus musculus

Alignment Length:	199	Identity:	58/199 - (29%)
Similarity:	96/199 - (48%)	Gaps:	8/199 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TSKKMTAPGPRPLVLCGPSGSGKSTLLKRLFAEFPSTFGFSISHTTRKPREGEEHGVHYYFVERP 90
            |...:.||.|. |:|.||:..||..|..||..:|.:.|.:...||||.|..||...|.|:|:.:.
Mouse   406 TLPSLDAPYPM-LILTGPAACGKRELAHRLCRQFSTYFRYGACHTTRPPYFGEGDRVDYHFISQE 469

  Fly    91 EMEAAIAGDEFIETAEFTGNLYGTSKAAVREIQAQGRVCILDIEQKGVEQIKRTDLNPILIFNNP 155
            ..:..:...:||.|..:..:.||.::..:..|...|....:.:|.:||..:|.:...|..|...|
Mouse   470 VFDEMLNMGKFILTFNYGNHNYGLNRDTIEGIARDGLASCIHMELEGVRSLKYSYFEPRYILVVP 534

  Fly   156 PSIKELERRLRKRG----SETEESLSKRLNAAQVELDYGLTPGNFHKIINNVDIDVAYEEFRNFV 216
            ...::.|..||::|    :|.|.::|:.....:|...|   ||.|..:||..|:|:||::....:
Mouse   535 MDKEKYEGYLRRKGLFSRAEIEIAVSRVDLYVKVNQKY---PGYFDAVINADDMDIAYQKLSELI 596

  Fly   217 VQEL 220
            .:.|
Mouse   597 REYL 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	54/188 (29%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	53/183 (29%)
Lrguk	XP_006506776.1	leucine-rich repeat	131..150	CDD:275380
		internalin_A	<132..>333	CDD:380193
		leucine-rich repeat	151..172	CDD:275380
		leucine-rich repeat	173..194	CDD:275380
		leucine-rich repeat	195..216	CDD:275380
		leucine-rich repeat	217..238	CDD:275380
		leucine-rich repeat	258..281	CDD:275380
		leucine-rich repeat	282..300	CDD:275380
		leucine-rich repeat	304..328	CDD:275380
		GMPK	416..537	CDD:238026	35/121 (29%)
		PHA03247	<678..1233	CDD:223021
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810