DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG11811 and PALS1

DIOPT Version :9

Sequence 1:NP_648408.1 Gene:CG11811 / 39213 FlyBaseID:FBgn0036099 Length:233 Species:Drosophila melanogaster
Sequence 2:NP_071919.2 Gene:PALS1 / 64398 HGNCID:18669 Length:675 Species:Homo sapiens


Alignment Length:202 Identity:70/202 - (34%)
Similarity:103/202 - (50%) Gaps:16/202 - (7%)


- Green bases have known domain annotations that are detailed below.


  Fly    25 LTSKKMT-----APGPRPLVLCGPSGSGKSTLLKRLFAEFPSTFGFSISHTTRKPREGEEHGVHY 84
            ||.::|:     |...||::|.||...|::.|.:||..:....|..::.||||..|:.|..|..|
Human   464 LTYEEMSLYHQPANRKRPIILIGPQNCGQNELRQRLMNKEKDRFASAVPHTTRSRRDQEVAGRDY 528

  Fly    85 YFVERPEMEAAIAGDEFIETAEFTGNLYGTSKAAVREIQAQGRVCILDIEQKGVEQIKRTDLNPI 149
            :||.|...||.||..:|||..||..||||||..:||::...|::|:|.:..:.::.::.:||.|.
Human   529 HFVSRQAFEADIAAGKFIEHGEFEKNLYGTSIDSVRQVINSGKICLLSLRTQSLKTLRNSDLKPY 593

  Fly   150 LIFNNPPSIKELERRLRKRG-----SETEESLSKRLNAAQVELDYGLTPGNFHKIINNVDIDVAY 209
            :||..|||.:.|...|.|.|     .|..|.:.|.....|....|      |...|.|.|:|.||
Human   594 IIFIAPPSQERLRALLAKEGKNPKPEELREIIEKTREMEQNNGHY------FDTAIVNSDLDKAY 652

  Fly   210 EEFRNFV 216
            :|....:
Human   653 QELLRLI 659

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG11811NP_648408.1 Guanylate_kin 34..219 CDD:279019 66/188 (35%)
guanyl_kin 36..216 CDD:213788 66/184 (36%)
PALS1NP_071919.2 Required for the correct localization of PALS1 and PATJ at cell-cell contacts and the normal formation of tight junctions and adherens junctions. /evidence=ECO:0000250|UniProtKB:Q9JLB2 1..345
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..34
Interaction with PARD6B. /evidence=ECO:0000250|UniProtKB:Q9JLB2 21..140
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 51..78
L27_N 123..170 CDD:401122
Interaction with LIN7C. /evidence=ECO:0000250|UniProtKB:Q9JLB2 181..243
L27 189..237 CDD:197794
PDZ_signaling 254..333 CDD:238492
SH3_MPP5 349..411 CDD:212969
GuKc 491..661 CDD:214504 61/175 (35%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG0194
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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