DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and Dlg2

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	XP_038945240.1	Gene:	Dlg2 / 64053	RGDID:	619895	Length:	1026	Species:	Rattus norvegicus

Alignment Length:	222	Identity:	68/222 - (30%)
Similarity:	113/222 - (50%)	Gaps:	27/222 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LSSSSSSSSAAASLTSKKMTAPGP---------RPLVLCGPSGSGKSTLLKRLFAEFPSTFGFSI 67
            :||::|.|.::.......:.:..|         ||:::.||.   |..:...|.:|||..||..:
  Rat   804 VSSNASDSESSCRGQEDLILSYEPVTRQEINYTRPVIILGPM---KDRINDDLISEFPDKFGSCV 865

  Fly    68 SHTTRKPREGEEHGVHYYFV-ERPEMEAAIAGDEFIETAEFTGNLYGTSKAAVREIQAQGRVCIL 131
            .||||..|:.|..|..|:|| .|.:||..|...:|||..::..||||||..:||.:..:|:.|||
  Rat   866 PHTTRPKRDYEVDGRDYHFVISREQMEKDIQEHKFIEAGQYNDNLYGTSVQSVRFVAERGKHCIL 930

  Fly   132 DIEQKGVEQIKRTDLNPILIFNNPPSIK---ELERRLRKRGSETEESLSKRLN-AAQVELDYGLT 192
            |:....:::::...|.||.||..|.|::   |:.:||      |||...|..: |.::|.::|
  Rat   931 DVSGNAIKRLQVAQLYPIAIFIKPKSLEPLMEMNKRL------TEEQAKKTYDRAIKLEQEFG-- 987

  Fly   193 PGNFHKIINNVDIDVAYEEFRNFVVQE 219
             ..|..|:....::..|.:.: .|::|
  Rat   988 -EYFTAIVQGDTLEDIYNQCK-LVIEE 1012

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	63/198 (32%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	61/184 (33%)
Dlg2	XP_038945240.1	L27_1	2..62	CDD:401120
		MAGUK_N_PEST	157..239	CDD:402306
		PDZ_signaling	240..324	CDD:238492
		PDZ_signaling	333..418	CDD:238492
		PDZ_assoc	420..487	CDD:402299
		PDZ_signaling	561..639	CDD:238492
		SH3_DLG2	676..749	CDD:212965
		Guanylate_kin	835..1013	CDD:395500	63/191 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810