DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and lrguk

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	XP_021330922.1	Gene:	lrguk / 559670	ZFINID:	ZDB-GENE-050419-232	Length:	739	Species:	Danio rerio

Alignment Length:	211	Identity:	63/211 - (29%)
Similarity:	97/211 - (45%)	Gaps:	18/211 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 TSKKMTAPGPRPLVLCGPSGSGKSTLLKRLFAEFPSTFGFSISHTTRKPREGEEHGVHYYFVERP 90
            |...:.||.|. |||.||...||..|..:|..||...|.:...||||.|..|||.|:.|:||...
Zfish   316 TLPSLDAPYPM-LVLTGPQACGKRELAHKLCQEFSDYFAYGACHTTRGPYFGEEDGLDYHFVTEE 379

  Fly    91 EMEAAIAGDEFIETAEFTGNLYGTSKAAVREIQAQGRVCILDIEQKGVEQIKRTDLNPILIFNNP 155
            |....|...:||:|.::.|:.||.|:.::..:..:|..|.:.:|.:||..:|.:...|..:...|
Zfish   380 EFHNMIQMGQFIQTMQYGGHWYGLSRESIERVAREGLACCVHMELEGVFSLKNSYFEPRYVLLIP 444

  Fly   156 PSIKELERRLRKRG----SETEESLSK-----RLNAAQVELDYGLTPGNFHKIINNVDIDVAYEE 211
            ..:......|:.||    ::.|.::|:     |:|..:        ||.|..||...|...||..
Zfish   445 SVVDNYVLFLKARGFYSNAQMETAVSRIDLYARINRER--------PGFFDSIIPCDDRAEAYRS 501

  Fly   212 FRNFVVQELKEQQKQG 227
            .:..|.:.|..::..|
Zfish   502 LKQLVKEYLGLEEHSG 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	58/193 (30%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	56/188 (30%)
lrguk	XP_021330922.1	LRR	<25..>247	CDD:227223
		leucine-rich repeat	61..82	CDD:275380
		leucine-rich repeat	83..104	CDD:275380
		leucine-rich repeat	105..126	CDD:275380
		leucine-rich repeat	127..148	CDD:275380
		leucine-rich repeat	149..168	CDD:275380
		leucine-rich repeat	170..191	CDD:275380
		leucine-rich repeat	192..210	CDD:275380
		leucine-rich repeat	211..238	CDD:275380
		GMPK	326..449	CDD:238026	41/123 (33%)
		Herpes_ICP4_C	520..>739	CDD:332854
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810