DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and PALS2

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	NP_001289966.1	Gene:	PALS2 / 51678	HGNCID:	18167	Length:	540	Species:	Homo sapiens

Alignment Length:	198	Identity:	63/198 - (31%)
Similarity:	106/198 - (53%)	Gaps:	13/198 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RPLVLCGPSGSGKSTLLKRLFAEFPSTFGFSISHTTRKPREGEEHGVHYYFVERPEMEAAIAGDE 100
            :.|||.|..|.|:.:|..|.....|:.||.::..|:|||||.|:.|..|.||.|.||||.|...:
Human   339 KTLVLIGAQGVGRRSLKNRFIVLNPTRFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGK 403

  Fly   101 FIETAEFTGNLYGTSKAAVREIQAQGRVCILDIEQKGVEQIKRTDLNPILIFNNPPSIKELERRL 165
            ::|..|:.||||||...::.|:...||.||||:..:.::.::.::..|.::|...|.::.| |.:
Human   404 YLEHGEYEGNLYGTKIDSILEVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETL-RAM 467

  Fly   166 RKRGSE--------TEESLSKRLN-AAQVELDYGLTPGNFHKIINNVDIDVAYEEFRNFVVQELK 221
            .|...:        |:..|.|.:: :|:::..|.   ..|..||.|.::|.|:|:.:..:.:...
Human   468 HKAVVDAGITTKLLTDSDLKKTVDESARIQRAYN---HYFDLIIINDNLDKAFEKLQTAIEKLRM 529

  Fly   222 EQQ 224
            |.|
Human   530 EPQ 532

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	61/191 (32%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	61/188 (32%)
PALS2	NP_001289966.1	L27	2..55	CDD:197794
		L27	57..108	CDD:397114
		PDZ_signaling	133..206	CDD:238492
		SH3_MPP6	219..279	CDD:212971
		Guanylate_kin	337..527	CDD:395500	61/191 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810