DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and Mpp2

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	NP_001343253.1	Gene:	Mpp2 / 50997	MGIID:	1858257	Length:	569	Species:	Mus musculus

Alignment Length:	247	Identity:	64/247 - (25%)
Similarity:	112/247 - (45%)	Gaps:	43/247 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VNRALSSSSSSSSAAASLTSKKM-----------------------TAPGP----RPLVLCGPSG 45
            |.|.|..:.:|.:...||:.||.                       .|..|    :.|||.|..|
Mouse   313 VKRDLELTPTSGTLCGSLSGKKKKRMMYLTTKNAEFDRHELLIYEEVARMPPFRRKTLVLIGAQG 377

  Fly    46 SGKSTLLKRLFAEFPSTFGFSISHTTRKPREGEEHGVHYYFVERPEMEAAIAGDEFIETAEFTGN 110
            .|:.:|..:|....|..:|.::.:|:|:|::.|..|..|.||.|.||||.|....::|..|:.||
Mouse   378 VGRRSLKNKLILWDPDRYGTTVPYTSRRPKDSEREGQGYSFVSRGEMEADIRAGRYLEHGEYEGN 442

  Fly   111 LYGTSKAAVREIQAQGRVCILDIEQKGVEQIKRTDLNPILIFNNPP---SIKELERRLRKRGSET 172
            ||||...::|.:.|.|:||:||:..:.|:.::..:..|.::|...|   :::.:.|...:.|..|
Mouse   443 LYGTRIDSIRGVVASGKVCVLDVNPQAVKVLRTAEFVPYVVFIEAPDYETLRAMNRAALESGVST 507

  Fly   173 EESLSKRL-----NAAQVELDYG------LTPGNFHKIINNVDIDVAYEEFR 213
            ::.....|     .:::::..||      |...|..:...  ::..|.|:.|
Mouse   508 KQLTEADLRRTVEESSRIQRGYGHYFDLSLVNSNLERTFR--ELQTAMEKLR 557

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	55/198 (28%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	54/192 (28%)
Mpp2	NP_001343253.1	L27	30..83	CDD:197794
		L27	85..136	CDD:308467
		PDZ_signaling	155..233	CDD:238492
		SH3_MPP2	246..304	CDD:212970
		GuKc	376..557	CDD:214504	49/182 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810