DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and MPP1

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	NP_002427.1	Gene:	MPP1 / 4354	HGNCID:	7219	Length:	466	Species:	Homo sapiens

Alignment Length:	171	Identity:	50/171 - (29%)
Similarity:	88/171 - (51%)	Gaps:	20/171 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RPLVLCGPSGSGKSTLLKRLFAEFPSTFGFSISHTTRKPREGEEHGVHYYFVERPEMEAAIAGDE 100
            :.|||.|.||.|:|.:...|.::.|..|.:.:.:|||.||:.||.|..|:|:...||...|:.:|
Human   283 KTLVLIGASGVGRSHIKNALLSQNPEKFVYPVPYTTRPPRKSEEDGKEYHFISTEEMTRNISANE 347

  Fly   101 FIETAEFTGNLYGTSKAAVREIQAQGRVCILDIEQKGVEQIKRTDLNPILIFNNPPSIKELERRL 165
            |:|...:.||::||....|.:|..|.::.|||||.:.::.::..:|:|.::|..|..
Human   348 FLEFGSYQGNMFGTKFETVHQIHKQNKIAILDIEPQTLKIVRTAELSPFIVFIAPTD-------- 404

  Fly   166 RKRGSETEESLSKRLNAAQVELDYGLTPGNFH----KIINN 202
              :|::||.....:.::..:...|.      |    .::||
Human   405 --QGTQTEALQQLQKDSEAIRSQYA------HYFDLSLVNN 437

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	50/171 (29%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	50/171 (29%)
MPP1	NP_002427.1	PDZ	71..149	CDD:366185
		SH3_MPP1	162..223	CDD:213013
		Interaction with PALS1. /evidence=ECO:0000269\|PubMed:17584769	268..466		50/171 (29%)
		Guanylate_kin	281..453	CDD:366206	50/171 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810