DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and Pals2

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	XP_006236558.1	Gene:	Pals2 / 362359	RGDID:	1311833	Length:	554	Species:	Rattus norvegicus

Alignment Length:	197	Identity:	61/197 - (30%)
Similarity:	107/197 - (54%)	Gaps:	14/197 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RPLVLCGPSGSGKSTLLKRLFAEFPSTFGFSISHTTRKPREGEEHGVHYYFVERPEMEAAIAGDE 100
            :.|||.|..|.|:.:|..|.....|:.||.::..|:|||||.|:.|..|.||.|.||||.|...:
  Rat   353 KTLVLIGAQGVGRRSLKNRFIVLNPARFGTTVPFTSRKPREDEKDGQAYKFVSRSEMEADIKAGK 417

  Fly   101 FIETAEFTGNLYGTSKAAVREIQAQGRVCILDIEQKGVEQIKRTDLNPILIFNNPPSIKELERRL 165
            ::|..|:.||||||...::.::...||.||||:..:.::.::.::..|.::|...|.::.| |.:
  Rat   418 YLEHGEYEGNLYGTKIGSILDVVQTGRTCILDVNPQALKVLRTSEFMPYVVFIAAPELETL-RAM 481

  Fly   166 RKRGSE--------TEESLSKRLN-AAQVELDYGLTPGNFHKIINNVDIDVAYEEFRNFVVQELK 221
            .|...:        |:..|.|.:: :|:::..|.   ..|..||.|.::|.|:|..:. .:::|:
  Rat   482 HKAVVDAGITTKLLTDSDLKKTVDESARIQRAYN---HYFDLIIVNDNLDKAFENLQT-AIEKLR 542

  Fly   222 EQ 223
            .:
  Rat   543 TE 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	60/191 (31%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	60/188 (32%)
Pals2	XP_006236558.1	L27	2..55	CDD:197794
		L27	57..108	CDD:397114
		PDZ_signaling	133..206	CDD:238492
		SH3_MPP6	233..293	CDD:212971
		Guanylate_kin	351..541	CDD:395500	60/192 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810