DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and vari

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	NP_724288.3	Gene:	vari / 35343	FlyBaseID:	FBgn0250785	Length:	636	Species:	Drosophila melanogaster

Alignment Length:	248	Identity:	80/248 - (32%)
Similarity:	116/248 - (46%)	Gaps:	45/248 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 AASLTSKKMTAPGP---RPLVLCGPSGSGKSTLLKRLFAEFPSTFGFSISHTTRKPREGEEHGVH 83
            |..|..:::|...|   :.|||.|.||.|:.||..||.......||..|.||:|..|..||:|..
  Fly   393 AELLLYEEVTRMPPFRRKTLVLIGVSGVGRRTLKNRLINSDVDKFGAVIPHTSRPKRALEENGSS 457

  Fly    84 YYFVERPEMEAAIAGDEFIETAEFTGNLYGTSKAAVREIQAQGRVCILD---------------- 132
            |:|::|.|||.|:..:||:|..|..||||||...:::::...||:||||
  Fly   458 YWFMDREEMEEAVRNNEFLEYGEHNGNLYGTHLQSIKDVINSGRMCILDCAPNALKILHNSQELM 522

  Fly   133 -----IEQKGVEQIK-------RTDLNPILIFNNPPSIKELERRLRKRGS-----ETEESLSKRL 180
                 :...|:||:|       .|..|..|.|:...||:...||.|...|     |.::.::...
  Fly   523 PFVIFVAAPGMEQLKTIYADRRATGSNRNLSFDRQSSIRFSSRRARTLESLASLYEDDDLVATVE 587

  Fly   181 NAAQVELDYGLTPGNFHKIINNVDIDVAYEEFRNFVVQELKE--QQKQGVSVN 231
            .::.|:..|   ...|..:|.|.|.|   |.||. ||:.|.:  .::|.|.||
  Fly   588 ESSFVQRKY---EKYFDMVIVNEDFD---ETFRQ-VVETLDQMSHEEQWVPVN 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	72/220 (33%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	69/212 (33%)
vari	NP_724288.3	L27	<105..128	CDD:280918
		PDZ_signaling	173..250	CDD:238492
		SH3_MPP	287..347	CDD:212796
		Guanylate_kin	408..622	CDD:279019	72/220 (33%)
		GuKc	418..622	CDD:214504	68/210 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.810