DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and GUK1

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	XP_005273161.1	Gene:	GUK1 / 2987	HGNCID:	4693	Length:	263	Species:	Homo sapiens

Alignment Length:	194	Identity:	109/194 - (56%)
Similarity:	138/194 - (71%)	Gaps:	0/194 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 GPRPLVLCGPSGSGKSTLLKRLFAEFPSTFGFSISHTTRKPREGEEHGVHYYFVERPEMEAAIAG 98
            ||||:||.||||:|||||||||..|....||||:|||||.||.|||:|..||||.|..|:..||.
Human    69 GPRPVVLSGPSGAGKSTLLKRLLQEHSGIFGFSVSHTTRNPRPGEENGKDYYFVTREVMQRDIAA 133

  Fly    99 DEFIETAEFTGNLYGTSKAAVREIQAQGRVCILDIEQKGVEQIKRTDLNPILIFNNPPSIKELER 163
            .:|||.|||:||||||||.||:.:||..|:|:||::.:||..||.|||.||.|...|||:..||:
Human   134 GDFIEHAEFSGNLYGTSKVAVQAVQAMNRICVLDVDLQGVRNIKATDLRPIYISVQPPSLHVLEQ 198

  Fly   164 RLRKRGSETEESLSKRLNAAQVELDYGLTPGNFHKIINNVDIDVAYEEFRNFVVQELKEQQKQG 227
            |||:|.:||||||.|||.|||.:::....||.|..:|.|..:|.||.|.:..:.:|:|:.|:.|
Human   199 RLRQRNTETEESLVKRLAAAQADMESSKEPGLFDVVIINDSLDQAYAELKEALSEEIKKAQRTG 262

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	105/184 (57%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	103/179 (58%)
GUK1	XP_005273161.1	Guanylate_kin	69..254	CDD:279019	105/184 (57%)
GUK1	XP_005273161.1	guanyl_kin	71..253	CDD:213788	103/181 (57%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153108
Domainoid	1	1.000	205	1.000	Domainoid score	I2949
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H665
Inparanoid	1	1.050	218	1.000	Inparanoid score	I3598
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG62608
OrthoDB	1	1.010	-	-		D1522834at2759
OrthoFinder	1	1.000	-	-		FOG0002663
OrthoInspector	1	1.000	-	-		oto89951
orthoMCL	1	0.900	-	-		OOG6_100603
Panther	1	1.100	-	-	LDO	PTHR23117
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R636
SonicParanoid	1	1.000	-	-		X2036
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800