DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and Dlg1

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	XP_038943929.1	Gene:	Dlg1 / 25252	RGDID:	2505	Length:	939	Species:	Rattus norvegicus

Alignment Length:	192	Identity:	66/192 - (34%)
Similarity:	99/192 - (51%)	Gaps:	19/192 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 RPLVLCGPSGSGKSTLLKRLFAEFPSTFGFSISHTTRKPREGEEHGVHYYFV-ERPEMEAAIAGD 99
            ||:::.||.   |..:...|.:|||..||..:.||||..|:.|..|..|:|| .|.:||..|...
  Rat   750 RPVIILGPM---KDRVNDDLISEFPDKFGSCVPHTTRPKRDYEVDGRDYHFVTSREQMEKDIQEH 811

  Fly   100 EFIETAEFTGNLYGTSKAAVREIQAQGRVCILDIEQKGVEQIKRTDLNPILIFNNPPS---IKEL 161
            :|||..::..:|||||..:||.:..:|:.||||:....:::::...|.||.||..|.|   |.|:
  Rat   812 KFIEAGQYNNHLYGTSVQSVRAVAEKGKHCILDVSGNAIKRLQIAQLYPISIFIKPKSMENIMEM 876

  Fly   162 ERRLRKRGSETEESLSKRLNAAQVELDYGLTPGNFHKIINNVDIDVAYEEFRNFVVQELKEQ 223
            .:||      |:|...|....| |.|:...|. :|..|:....:    |:..|.|.|.::||
  Rat   877 NKRL------TDEQARKTFERA-VRLEQEFTE-HFTAIVQGDTL----EDIYNQVKQIIEEQ 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	63/186 (34%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	62/183 (34%)
Dlg1	XP_038943929.1	PDZ_signaling	224..308	CDD:238492
		PDZ_signaling	317..403	CDD:238492
		PDZ_assoc	404..465	CDD:402299
		PDZ	463..547	CDD:214570
		SH3_DLG1	582..648	CDD:212964
		Guanylate_kin	748..926	CDD:395500	64/190 (34%)
		L27_1	2..62	CDD:401120
		MAGUK_N_PEST	106..223	CDD:402306
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810