DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and PDZD2

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	XP_005248326.1	Gene:	PDZD2 / 23037	HGNCID:	18486	Length:	2873	Species:	Homo sapiens

Alignment Length:	207	Identity:	40/207 - (19%)
Similarity:	69/207 - (33%)	Gaps:	59/207 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LSSSSSSSSAAASLTSKKMTAP-----GPRPLVLC-------GPSGSGKSTLLKRLFAEFPSTFG 64
            |.:.::...|:|.:.|.|.:.|     .||....|       ||..|..|:||:
Human  1617 LPTQAAICPASAKVLSLKYSTPRESVASPREKAACLPGSYTSGPDSSQPSSLLE----------- 1670

  Fly    65 FSISHTTRKPREGEEHGVHYYFVERPEMEAAIAGDEFIETAEFTGNLYGTSKAAVREIQAQGRVC 129
                      ...:||..|        .:.:.:.:.....||.|..:...|.|
Human  1671 ----------MSSQEHETH--------ADISTSQNHRPSCAEETTEVTSASSA------------ 1705

  Fly   130 ILDIEQKGVEQIKRTDLNPILIFNNPPSIKELERRLRKRGSETEESLSKRLNAAQVELDYGL-TP 193
               :|...:.::.|...:|.:|.::|..:..||..|  ...||.......:|||.....:.: .|
Human  1706 ---MENSPLSKVARHFHSPPIILSSPNMVNGLEHDL--LDDETLNQYETSINAAASLSSFSVDVP 1765

  Fly   194 GNFHKIINNVDI 205
            .|...::.|:.|
Human  1766 KNGESVLENLHI 1777

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	34/180 (19%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	33/178 (19%)
PDZD2	XP_005248326.1	PDZ_signaling	335..416	CDD:238492
		PDZ_signaling	589..670	CDD:238492
		PDZ_signaling	726..810	CDD:238492
		PDZ_signaling	2623..2694	CDD:238492
		PDZ	2785..2867	CDD:214570
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900