DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and Mpp4

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	NP_001158154.1	Gene:	Mpp4 / 227157	MGIID:	2386681	Length:	654	Species:	Mus musculus

Alignment Length:	213	Identity:	67/213 - (31%)
Similarity:	108/213 - (50%)	Gaps:	23/213 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VNRALSSSSSSSSAAAS-----LTSKKMTAPGPRPLVLCGPSGSGKSTLLKRLFAEFPSTFGFSI 67
            ::.:|..|.|..||..:     :..::..|...|.:||.||||.|.:.|.::|....||.|..::
Mouse   413 LHASLCCSCSCYSAVGAPYEEVVRYQRQPADKHRLIVLVGPSGVGVNELRRQLIGCNPSCFQSAV 477

  Fly    68 SHTTRKPREGEEHGVHYYFVERPEMEAAIAGDEFIETAEFTGNLYGTSKAAVREIQAQGRVCILD 132
            .||||.|:..|..|..|::|.|...|:.:.|.:.:|..|:.|:|||||..||..:..:|::||:|
Mouse   478 PHTTRFPKSYEMDGREYHYVSRETFESLMYGHKMLEYGEYKGHLYGTSVNAVHAVLDEGKICIMD 542

  Fly   133 IEQKGVEQIKRTDLNPILIFNNPPSIKELERRLRKRGSET----------EESLSKRLNAAQ-VE 186
            :|.:.::..:..||.|.:||..||:...: |..||....|          :|.|.:....|| :|
Mouse   543 LEPQDIQSARTRDLKPYVIFIKPPNTSSM-RHSRKNAKITTDYYVDMKFKDEDLQEMEELAQKME 606

  Fly   187 LDYGLTPGNF--HKIINN 202
            ..:    |.|  |.|:|:
Mouse   607 SQF----GQFFDHVIVND 620

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	61/182 (34%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	61/180 (34%)
Mpp4	NP_001158154.1	L27	<66..100	CDD:197794
		L27	108..154	CDD:280918
		PDZ_signaling	171..250	CDD:238492
		SH3_MPP4	264..324	CDD:212967
		Guanylate_kin	446..636	CDD:279019	61/180 (34%)
		GuKc	454..637	CDD:214504	56/172 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810