DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and Cask

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	XP_011245733.1	Gene:	Cask / 12361	MGIID:	1309489	Length:	972	Species:	Mus musculus

Alignment Length:	227	Identity:	60/227 - (26%)
Similarity:	93/227 - (40%)	Gaps:	68/227 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 KMTAPGPRPLVLCGPSGSGKSTLLKRLFAEFPSTFGFSISHTTRKPREGEEHGVHYYFVERPEME 93
            |:.|...:.|||.|..|.|:..:...|..:.|..|.:.|.||||.|::.||:|.:||||...:|.
Mouse   739 KLPAFKRKTLVLLGAHGVGRRHIKNTLITKHPDRFAYPIPHTTRPPKKDEENGKNYYFVSHDQMM 803

  Fly    94 AAIAGDEFIETAEFTGNLYGTSKAAVREIQAQGRVCILDIEQKGVEQ------------------ 140
            ..|:.:|::|.......:|||....:|:|..||.:.|||:|.:|:|:
Mouse   804 QDISNNEYLEYGSHEDAMYGTKLETIRKIHEQGLIAILDVEPQGLEKSSGQGWLEAKSQSWSWSS 868

  Fly   141 ----------------------IKRTDLNPILIFNNPPSIKELERRLRKRGSETEESLSKRLNAA 183
                                  ::..:..|.::|...|:|..        |...:|||.:    .
Mouse   869 TSSPWVPHWSSPERRFLLALKVLRTAEFAPFVVFIAAPTITP--------GLNEDESLQR----L 921

  Fly   184 QVELD---------YGLTPGNFHKIINNVDID 206
            |.|.|         :.||      |||| :||
Mouse   922 QKESDVLQRTYAHYFDLT------IINN-EID 946

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	58/222 (26%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	58/220 (26%)
Cask	XP_011245733.1	STKc_CASK	8..313	CDD:270996
		L27	354..407	CDD:197794
		L27	412..462	CDD:397114
		PDZ_signaling	494..574	CDD:238492
		SH3_CASK	622..683	CDD:213014
		Guanylate_kin	744..957	CDD:395500	58/222 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910