DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and dlg1a

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	XP_005165955.1	Gene:	dlg1a / 114446	ZFINID:	ZDB-GENE-010724-8	Length:	935	Species:	Danio rerio

Alignment Length:	232	Identity:	68/232 - (29%)
Similarity:	123/232 - (53%)	Gaps:	34/232 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 VNRALSSSSSSSSAA-----------ASLTSKKMTAPGPRPLVLCGPSGSGKSTLLKRLFAEFPS 61
            |::.::|::|.|.::           .::|.::::.  .||:::.||.   |..:...|.:|||.
Zfish   709 VDQHVTSNASDSESSFRGQEDYVLSYETVTQQEVSY--SRPVIILGPM---KDRINDDLISEFPD 768

  Fly    62 TFGFSISHTTRKPREGEEHGVHYYFV-ERPEMEAAIAGDEFIETAEFTGNLYGTSKAAVREIQAQ 125
            .||..:.||||..|:.|..|..|:|| .|.:||..|...:|||..::..:|||||..:|||:..:
Zfish   769 KFGSCVPHTTRPKRDYEVDGRDYHFVNSREQMEKDIQDHKFIEAGQYNNHLYGTSVQSVREVAEK 833

  Fly   126 GRVCILDIEQKGVEQIKRTDLNPILIFNNPPSIK---ELERRL-RKRGSETEESLSKRLNAAQVE 186
            |:.||||:....:::::...|.||.:|..|.|::   |:.:|| .::|.:|.:      .|.::|
Zfish   834 GKHCILDVSGNAIKRLQLAQLYPIAVFIKPKSVENILEMNKRLMEEQGRKTYD------RAMKLE 892

  Fly   187 LDYGLTPGNFHKIINNVDIDVAYEEFRNFVVQELKEQ 223
            .::   ..:|..|:....:    ||..|.|.|.::||
Zfish   893 QEF---LEHFTAIVQGDTL----EEIYNQVKQIIEEQ 922

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	60/189 (32%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	59/184 (32%)
dlg1a	XP_005165955.1	L27_1	4..62	CDD:286187
		MAGUK_N_PEST	109..230	CDD:287565
		PDZ_signaling	231..315	CDD:238492
		PDZ_signaling	324..410	CDD:238492
		PDZ_assoc	411..474	CDD:287558
		PDZ	472..556	CDD:214570
		SH3	588..661	CDD:302595
		Guanylate_kin	744..922	CDD:279019	61/195 (31%)
		GuKc	755..922	CDD:214504	57/179 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810