DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG11811 and Card10

DIOPT Version :9

Sequence 1:	NP_648408.1	Gene:	CG11811 / 39213	FlyBaseID:	FBgn0036099	Length:	233	Species:	Drosophila melanogaster
Sequence 2:	XP_036014949.1	Gene:	Card10 / 105844	MGIID:	2146012	Length:	1144	Species:	Mus musculus

Alignment Length:	192	Identity:	42/192 - (21%)
Similarity:	68/192 - (35%)	Gaps:	71/192 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 SGKSTLLKR---LFAEFPS--TFGFSISHTTRKPREGEEHGVHYYFVERPEMEAA---------- 95
            |.:|.|.||   |....|:  |.|.|......:|....|..:..|.:.||.:.:|
Mouse   901 SPRSNLKKRALGLVRPKPAGGTAGDSAEQLPAEPCSELERSLKPYSLVRPLLVSALRPVVLLPEC 965

  Fly    96 --------------------------IAGDEFIETAEFTGNLYGTSKA---------AVREIQAQ 125
                                      ::|:|     :.|.:..|..||         .:|.||..
Mouse   966 LAPRLIRNLLDLPSSRLDFQVCPAESLSGEE-----QCTSSAPGAPKAWPATAGLGSRIRAIQES 1025

  Fly   126 --GRVCILDIEQKGVEQIKRTDLNPILIF-----NNPPSIKELERR--------LRK-RGSE 171
              .:.|:|::..:||.::..:::.||:|.     .|...|:.|..|        ||: ||||
Mouse  1026 VGKKHCLLELGARGVRELVHSEVYPIVIHVEVTEKNVREIRGLLGRPGWRDSELLRQCRGSE 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG11811	NP_648408.1	Guanylate_kin	34..219	CDD:279019	42/192 (22%)
CG11811	NP_648408.1	guanyl_kin	36..216	CDD:213788	42/192 (22%)
Card10	XP_036014949.1	CARD_CARD10_CARMA3	150..235	CDD:260069
		Smc	<270..>573	CDD:224117
		SH3	822..884	CDD:418401
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0194
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900