DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment simj and GATAD2B

DIOPT Version :9

Sequence 1:	NP_001261685.1	Gene:	simj / 39212	FlyBaseID:	FBgn0010762	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	NP_065750.1	Gene:	GATAD2B / 57459	HGNCID:	30778	Length:	593	Species:	Homo sapiens

Alignment Length:	691	Identity:	210/691 - (30%)
Similarity:	293/691 - (42%)	Gaps:	196/691 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 AALSNRDLRALTANNAGLTITPSASPATNNGTTSNSSNTNSNSSSTTTTTNNNNNSSSNTNSSSA 95
            |.|..:||       |.|.: |...|...:|:.........|.       |...:..:.|.....
Human    47 ALLKRKDL-------ANLEV-PHELPTKQDGSGVKGYEEKLNG-------NLRPHGDNRTAGRPG 96

  Fly    96 NNNNNNNSINASDGVTGATSGSIGGGQDENKVQRRVLRPRTEPK--SYAEAPDIVLL------PA 152
            ..|.|:..::.|                         ..|:||:  ....:|||::|      ..
Human    97 KENINDEPVDMS-------------------------ARRSEPERGRLTPSPDIIVLSDNEASSP 136

  Fly   153 RTNGRQQNGNIDSETDDEEMPPYVPIKELSHAELKEREKSLRKLRQDLRNEETKLMLLKKLKQSQ 217
            |::.|.           ||......::......::||::.:::||.:||.||.:|:|||||:||
Human   137 RSSSRM-----------EERLKAANLEMFKGKGIEERQQLIKQLRDELRLEEARLVLLKKLRQS- 189

  Fly   218 QVMKENLVVTPTSVSPNNPLSAIPAALTSKGSLSVTPTSAVPLPAH-SKGSRSSLSGSGGPAVSI 281
            |:.||| ||..|.|..|              :.|:..    |.||| .:...|.|....| |..:
Human   190 QLQKEN-VVQKTPVVQN--------------AASIVQ----PSPAHVGQQGLSKLPSRPG-AQGV 234

  Fly   282 SATNSRTGSSSSAAAAASAIAAAAMSGQHRSGSNSILPPPRSSLPAGATLAAGTTITPATSSSHR 346
            ...|.||....|..               ||.:|:.||   ..|.:...:|.    .||.....|
Human   235 EPQNLRTLQGHSVI---------------RSATNTTLP---HMLMSQRVIAP----NPAQLQGQR 277

  Fly   347 SSNLPP-----RTNLPNLTITPSVTITPTSAPPSSLKPRNVP--GTISNSVSITPALPLSQSHQN 404
            .   ||     ||..||:  .|::...|.|:       .:||  .|.|:::.:..|     ||..
Human   278 G---PPKPGLVRTTTPNM--NPAINYQPQSS-------SSVPCQRTTSSAIYMNLA-----SHIQ 325

  Fly   405 QHNDQKNDRSTPREDAQT-PAQRQAAAKMALRKQLEKTLLQIPPPKPPPPEMHFIPNPSNTDFVY 468
            .....:.....|...|.| .|..|||||:|||||||||||:|||||||.|.:||:|:.:|::|:|
Human   326 PGTVNRVSSPLPSPSAMTDAANSQAAAKLALRKQLEKTLLEIPPPKPPAPLLHFLPSAANSEFIY 390

  Fly   469 LLGLETVVDYLTVNKKANAVAA-----PFRCAQCKIDFTPVWKWEKQTNKDPKVICEQCVTSNVK 528
            ::|||.||..: ::.:..:.|:     ||.||||:.||||.||.|    |:.|::||||:|||.|
Human   391 MVGLEEVVQSV-IDSQGKSCASLLRVEPFVCAQCRTDFTPHWKQE----KNGKILCEQCMTSNQK 450

  Fly   529 KALKAEHTNRLKQAFVKALQQEQEIEQRLASQSSPSPVDNHGSSGGGNSLSVSAVSSNSSSSHMQ 593
            ||||||||||||.||||||||||||||||..|::.||.            :..||||.|
Human   451 KALKAEHTNRLKNAFVKALQQEQEIEQRLQQQAALSPT------------TAPAVSSVS------ 497

  Fly   594 REREQLQASHASAAAALVNLPPSVTVIPTKCQTPTPATPRPTPPPPQSQATPPPSSGGSRSSRAA 658
             ::|.:...|                           |.|..|.|..|.....|:|..|..|
Human   498 -KQETIMRHH---------------------------TLRQAPQPQSSLQRGIPTSARSMLS--- 531

  Fly   659 ATAAAAAIAAQQAGILS-PGPSPAH-------HHEPTTSSR 691
             ..|.|...:...|:|. ||.:.|:       |..|:.:.|
Human   532 -NFAQAPQLSVPGGLLGMPGVNIAYLNTGIGGHKGPSLADR 571

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
simj	NP_001261685.1	P66_CC	185..222	CDD:293171	17/36 (47%)
GATAD2B	NP_065750.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	62..123		11/92 (12%)
		P66_CC	159..194	CDD:406867	17/35 (49%)
		CR1, interaction with MBD2 and MBD3. /evidence=ECO:0000269\|PubMed:12183469	165..195		16/30 (53%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..235		7/22 (32%)
		CR2, histone tail-binding. /evidence=ECO:0000269\|PubMed:16415179	340..480		89/144 (62%)
		GATA	420..454	CDD:395253	23/37 (62%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165148039
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3740
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	248	1.000	Inparanoid score	I3257
Isobase	1	0.950	-	0	Normalized mean entropy	S7145
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003555
OrthoInspector	1	1.000	-	-		otm40445
orthoMCL	1	0.900	-	-		OOG6_111121
Panther	1	1.100	-	-	O	PTHR13455
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9898
SonicParanoid	1	1.000	-	-		X2908
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.730