DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment simj and Gatad2a

DIOPT Version :9

Sequence 1:	NP_001261685.1	Gene:	simj / 39212	FlyBaseID:	FBgn0010762	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	XP_006252949.1	Gene:	Gatad2a / 290669	RGDID:	1310596	Length:	633	Species:	Rattus norvegicus

Alignment Length:	630	Identity:	198/630 - (31%)
Similarity:	275/630 - (43%)	Gaps:	133/630 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 TGATSGSIGGGQDENKVQRRVLRPRTEPKSYAEAPDIVLLPARTNGRQQNGNIDSETDDEEMPPY 175
            ||:..|.:|.|..:.:.....::....|.|    ||:::|                 .|.|.|..
  Rat    67 TGSGEGLLGDGPVDMRTSHSDMKSEKRPPS----PDVIVL-----------------SDSEQPSS 110

  Fly   176 VPIKELSHAELK-------------EREKSLRKLRQDLRNEETKLMLLKKLKQSQQVMKENLVVT 227
            ..:..|:...||             |||:.:::|:::||.||.||:|||||:|| |:.||.....
  Rat   111 PRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKKLRQS-QIQKEATAQK 174

  Fly   228 PTSVSPNNPLSAIPAALTSKGSLSVTPTSAVPLPAHSKGSRSSLSGSGG--PAVSISATNSRTGS 290
            ||:               |.||...||...|..|.:....:.||..|..  |...|.....|.|.
  Rat   175 PTA---------------SSGSTVTTPPPLVRGPQNIPAGKPSLQTSSTRIPGSIIPPPLVRGGQ 224

  Fly   291 SSSAAAAASAIAAAAMSGQHRSGSNSILPPPRSSLPAGATLAAGTTITPATSS--SHRSSNLPPR 353
            ..||.....|             |:.::.||         |..|..::....:  .|.|:..||.
  Rat   225 QVSAKLGPQA-------------SSQVVMPP---------LVRGAQVSQQIHNIRQHSSTGPPPL 267

  Fly   354 TNLPNLTITPSVTITPTSAPPSSL-KPRNVPGTISNSVSITPALPLSQSHQNQHNDQKNDRSTPR 417
            ...|..:: ||:.|.........| :..|||.|   |:.:....|.:.|.:..........|||.
  Rat   268 LLAPRASV-PSMQIQGQRIIQQGLIRVANVPNT---SLLVNIPQPTAASLKGTTVGSAQANSTPS 328

  Fly   418 E------DAQTPAQRQAAAKMALRKQLEKTLLQIPPPKPPPPEMHFIPNPSNTDFVYLLGLETVV 476
            .      .|::||.||||||:|||||||||||:|||||||.|||:|:|:.:|.:|:||:|||.||
  Rat   329 SVASVVASAESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEFIYLVGLEEVV 393

  Fly   477 DYLTVNK----KANAVAA-----PFRCAQCKIDFTPVWKWEKQTNKDPKVICEQCVTSNVKKALK 532
            ..|...:    .|.:.||     |:.|.|||.|||..|:     .|...|:||.|:|||.|||||
  Rat   394 QNLLETQAGRISATSAAAVLSREPYMCVQCKTDFTCRWR-----EKGGAVMCENCMTSNQKKALK 453

  Fly   533 AEHTNRLKQAFVKALQQEQEIEQRLASQSSPSPVDNHGSSGGGNSLSVSAVSSNSSSSHMQRERE 597
            .|||:|||.|||||||||||:||||..|             |..:.|:.|.::....|..|..:.
  Rat   454 VEHTSRLKAAFVKALQQEQEMEQRLLQQ-------------GVGTASIKAETAAPHPSLKQVIKP 505

  Fly   598 QLQASHASAAAALVNLPPSVTVIPTKCQTP--TPATPR------PTPPPPQ--SQATPPPSSGGS 652
            :.:.:..|..|...|   :.:|:.|..|..  :..|||      ...|..|  :.||...|..|.
  Rat   506 RRKLAFRSGEARDWN---NGSVLQTSSQLSRGSATTPRGVLHTFSQSPKLQNAASATALVSRTGR 567

  Fly   653 RSSRAAATAAAAAIAAQQAGILSPG------PSPAHHHEPTTSSR 691
            .|.|...|:...|...::..:.:.|      ||.|.|...:...|
  Rat   568 HSERVVGTSKGTASNWKKTPLSTGGTLAFVSPSLAVHKSSSAVDR 612

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
simj	NP_001261685.1	P66_CC	185..222	CDD:293171	20/49 (41%)
Gatad2a	XP_006252949.1	P66_CC	133..169	CDD:406867	18/36 (50%)
Gatad2a	XP_006252949.1	ZnF_GATA	420..453	CDD:421870	19/37 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166341913
Domainoid	1	1.000	209	1.000	Domainoid score	I2751
eggNOG	1	0.900	-	-		E1_KOG3740
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	245	1.000	Inparanoid score	I3199
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003555
OrthoInspector	1	1.000	-	-		otm44587
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13455
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2908
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.850