DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment simj and Gatad2a

DIOPT Version :9

Sequence 1:	NP_001261685.1	Gene:	simj / 39212	FlyBaseID:	FBgn0010762	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	XP_017168203.1	Gene:	Gatad2a / 234366	MGIID:	2384585	Length:	633	Species:	Mus musculus

Alignment Length:	582	Identity:	192/582 - (32%)
Similarity:	269/582 - (46%)	Gaps:	165/582 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 TGATSGSIGGGQDENKVQRRVLRPRTEPKSYAEAPDIVLLPARTNGRQQNGNIDSETDDEEMPPY 175
            ||:..|.:|.|..:.:.....::....|.|    ||:::|                 .|.|.|..
Mouse    67 TGSGEGLLGDGPVDMRTSHSDMKSEKRPPS----PDVIVL-----------------SDSEQPSS 110

  Fly   176 VPIKELSHAELK-------------EREKSLRKLRQDLRNEETKLMLLKKLKQSQQVMKENLVVT 227
            ..:..|:...||             |||:.:::|:::||.||.||:|||||:|| |:.||.....
Mouse   111 PRVNGLTTVALKDTSTEALLKSSPEERERMIKQLKEELRLEEAKLVLLKKLRQS-QIQKEATAQK 174

  Fly   228 PTSVSPNN-----PL----SAIPAALTS-KGSLSVTPTSAVPLPAHSKGSRSSLSGSGGPAVSIS 282
            ||:.|.:.     ||    ..|||..|| :.|.:..|.|.:|.|....|.:  :|...||
Mouse   175 PTASSGSTVTTPPPLVRGTQNIPAGKTSLQTSSTRIPGSIIPPPLVRGGQQ--VSAKLGP----- 232

  Fly   283 ATNSRTGSSSSAAAAASAIAAAAMS------GQHRS-GSNSILPPPRSSLPA----GATLAAGTT 336
                   .:||.......:..|.:|      .||.| |...:|..||:|:|:    |..:.....
Mouse   233 -------QASSQVVMPPLVRGAQVSQQIHNIRQHSSTGPPPLLLAPRASVPSMQIQGQRIIQQGL 290

  Fly   337 ITPATSSSHRSSNLPPRTNLPNLTITPSVTITPTSAPPSSLKPRNVPGTISNSVSITPALPLSQS 401
            |..|              |:||.::..::. .||:|   |:|...|....:||...:.|..::
Mouse   291 IRVA--------------NVPNTSLLVNIP-QPTAA---SMKGTAVASAQANSTPTSVASVVA-- 335

  Fly   402 HQNQHNDQKNDRSTPREDAQTPAQRQAAAKMALRKQLEKTLLQIPPPKPPPPEMHFIPNPSNTDF 466
                             .|::||.||||||:|||||||||||:|||||||.|||:|:|:.:|.:|
Mouse   336 -----------------SAESPASRQAAAKLALRKQLEKTLLEIPPPKPPAPEMNFLPSAANNEF 383

  Fly   467 VYLLGLETVVDYLTVNK----KANAVAA-----PFRCAQCKIDFTPVWKWEKQTNKDPKVICEQC 522
            :||:|||.||..|...:    .|.|.||     |:.|.|||.|||..|:     .|...|:||.|
Mouse   384 IYLVGLEEVVQNLLETQAGRISATAAAAVLSREPYMCVQCKTDFTCRWR-----EKGGAVMCENC 443

  Fly   523 VTSNVKKALKAEHTNRLKQAFVKALQQEQEIEQRLASQ-----------SSPSP----------- 565
            :|||.|||||.|||:|||.|||||||||||:||||..|           ::|.|
Mouse   444 MTSNQKKALKVEHTSRLKAAFVKALQQEQEMEQRLLQQGVGTASIKAEPAAPHPTLKQVIKPRRK 508

  Fly   566 ---------VDNHGSSGGGNSLSVSAVSSNSSSS------HMQREREQLQASHASAAAALVN 612
                     |.|:||     ||..|:..|..|::      |...:..:||  :|::|.|||:
Mouse   509 LAFRSGEARVWNNGS-----SLQASSQLSRGSATAPRGVLHTFSQSPKLQ--NAASATALVS 563

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
simj	NP_001261685.1	P66_CC	185..222	CDD:293171	20/49 (41%)
Gatad2a	XP_017168203.1	P66_CC	133..169	CDD:374633	18/36 (50%)
Gatad2a	XP_017168203.1	ZnF_GATA	420..452	CDD:392140	18/36 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167838131
Domainoid	1	1.000	210	1.000	Domainoid score	I2824
eggNOG	1	0.900	-	-		E1_KOG3740
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	245	1.000	Inparanoid score	I3266
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003555
OrthoInspector	1	1.000	-	-		otm42524
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13455
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2908
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.940