DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment simj and dcp-66

DIOPT Version :9

Sequence 1:	NP_001261685.1	Gene:	simj / 39212	FlyBaseID:	FBgn0010762	Length:	937	Species:	Drosophila melanogaster
Sequence 2:	NP_871831.3	Gene:	dcp-66 / 172507	WormBaseID:	WBGene00000938	Length:	724	Species:	Caenorhabditis elegans

Alignment Length:	942	Identity:	220/942 - (23%)
Similarity:	323/942 - (34%)	Gaps:	310/942 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    44 NNAGLTITPSASPAT------NNGTT--SNSSNTNSNSSSTTTTTNNNNNSSSN--TNSSSANNN 98
            |..||:|..|||.|.      .||..  ..:...:.|.:||:..|::...|.|:  ..|:.|:..
Worm    19 NGNGLSIEESASTAVAALAHIQNGAVLFHGTPTKDLNGASTSIDTDDLQLSPSDLRRRSTRASAL 83

  Fly    99 NNNNSINASDGVTGATSGSIGGGQDENKVQRRVLRPRTEPKSYAEAPDIVLLPARTNGRQ----- 158
            .....|...|.:   ..|......|::.::...|......:|   ||....|   .||::
Worm    84 KAQEKIKLKDDI---VQGPQKRANDDDDMEDEELGDEINEQS---APKKRRL---ENGKEFDQTC 139

  Fly   159 --------QNGNIDSETDDEEMPPY--------------VPIKELSHAELKEREKSLRKLRQDLR 201
                    ..|.:.:.||:.|....              :..||....:|:||....|:....||
Worm   140 FRFGLRANNEGEVYAMTDESENSSIHESEMEVVRYHYEKMKNKEPDEEQLRERLNMRREAENQLR 204

  Fly   202 NEETKLMLLKKLKQSQQVMKENLVVTPTSVSPNNPLSAIPAALTSKGSLSVTPTSAVPLPAHSKG 266
            .||.||::|:|:|.||......|                 ||.|....|: ..|||...||.:..
Worm   205 EEEAKLLVLRKMKDSQTRAITKL-----------------AAETKAADLA-EATSAAYKPAVATN 251

  Fly   267 SRSSLSGSGGPAVSISATNSRTGS-----------------SSSAAAAASAIAAAAMSGQHRSGS 314
            .:|..:|..    |:..:|::|.:                 ||.:.||..|...|..:
Worm   252 GKSVTNGKN----SMIESNNKTMNGLKNLSIPQQLELLQKLSSQSPAAKQAYIMAKKN------- 305

  Fly   315 NSILPPPRSSLPAGATLAAGTTITPATSSSHRSSNLPPRTNLPNLTITPSVTITPTSAPPSSLKP 379
                       ||..|......||               .|..||.....::...|:|
Worm   306 -----------PAQTTQLFQQLIT---------------INNQNLQKQKELSAAETNA------- 337

  Fly   380 RNVPGTISNSVSITPALPLSQSHQNQHNDQKNDRSTPREDAQTPAQRQAAAKMALRKQLEKTLLQ 444
                     |.|.:||  :.||.|.|...|.....:...:.||||||..||::|.|.|.:|.|..
Worm   338 ---------SASASPA--VQQSQQAQQPQQAQITQSKLLNQQTPAQRIQAARLAFRAQADKQLTT 391

  Fly   445 IPPPKPPPPEMHFIPNPSNTDFVYLLGLETVVDYLTVNKKANAV--AAP-FRCAQCKIDFTPVWK 506
            ||..|..|.::.|:|||:.:.|:.|.||:.||.:: :..::|..  |.| :.|.:||.:....||
Worm   392 IPTQKSQPHDITFLPNPNASAFLALHGLDLVVQHV-LKDRSNETPYAGPSYECEECKTECAHTWK 455

  Fly   507 WEKQTNKDPKVICEQCVTSNVKKALKAEHTNRLKQAFVKALQQE---QEIEQRLASQSSPSPVDN 568
            ....|..|..:.||.||.|..|:..:.:.|..||:||.|...||   ||.|:::|
Worm   456 AIGSTQDDLHLYCENCVRSAQKRKNRTDQTALLKRAFQKITAQEKLLQEFEKKIA---------- 510

  Fly   569 HGSSGGGNSLSVSAVSSNSSSSHMQREREQLQASHASAAAALVNLPPSVTVIPTKCQTPTPATPR 633
                                      |.:..|.:.|.|||     |.:...|||. .|.|.::..
Worm   511 --------------------------EGQLEQYAEAKAAA-----PATSQTIPTS-STATVSSIP 543

  Fly   634 PTPPPPQSQATPPPSSGGSRSSRAAATAAAAAIAAQQAGILSPGPSPAHHHEPTTSSRSSRNDRL 698
            ..|..||.    |.|:|.|..::|..|                  |...|..|.:||.|::
Worm   544 LVPRLPQI----PSSTGSSTPTQAVKT------------------STPIHSTPKSSSSSAK---- 582

  Fly   699 DHHHQSQQQQQRDQRERDQQQRDQQSQQQAQNYDKYSAATLAAAAHLSALGGMGGLN-INSLASL 762
                            :...|..|||.|                          |:| :.|.|.|
Worm   583 ----------------KTAAQLQQQSMQ--------------------------GMNQLFSTAML 605

  Fly   763 GNLGNLGNLSQLGNLAALGGLGNFGGASTGSANPAAGLSGSSPAATAAAMQAFQQQLFRALGQGL 827
            .|...:..:.|:....|:|     |||:..:.|..|.|      ..|.||||.|.|:.||
Worm   606 RNNPQMQQMLQMYQALAMG-----GGAANMANNQMAML------FQAQAMQAAQAQVARA----- 654

  Fly   828 GGNPQHMMQFAPLLYSYQMAMAQAAQVAGEMTMALTGKFITGYQECDSVTFNNNNKKSSSSSGSA 892
                             |.|.|||||.......|..                ..|::::..| ..
Worm   655 -----------------QAAKAQAAQAQAAQAQAQA----------------QANREANQQS-ML 685

  Fly   893 KNSSSSNSMAEVQRAAELQRQYLLEMIPPQQQ 924
            ..:..||....||...:||:      :.|:||
Worm   686 IQALMSNGQVNVQALQQLQK------LTPEQQ 711

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
simj	NP_001261685.1	P66_CC	185..222	CDD:293171	15/36 (42%)
dcp-66	NP_871831.3	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159973
Domainoid	1	1.000	105	1.000	Domainoid score	I4190
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	116	1.000	Inparanoid score	I3390
Isobase	1	0.950	-	0	Normalized mean entropy	S7145
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003555
OrthoInspector	1	1.000	-	-		oto18500
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13455
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R9898
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.060