DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8003 and ANKMY2

DIOPT Version :9

Sequence 1:	NP_001261683.1	Gene:	CG8003 / 39210	FlyBaseID:	FBgn0036096	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	NP_064715.1	Gene:	ANKMY2 / 57037	HGNCID:	25370	Length:	441	Species:	Homo sapiens

Alignment Length:	402	Identity:	157/402 - (39%)
Similarity:	215/402 - (53%)	Gaps:	41/402 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QLDDVQRQLLDHLAKNDTSGFKQLLS--GVRNVNFVDDTGMSCLAHASFKGNREAVQLLLDMGAD 72
            :|...:::||:.:.|........|||  .|| ||.:|:.||:.|.||::||..:..:|||..|||
Human     8 ELTQEEKELLEVIGKGTVQEAGTLLSSKNVR-VNCLDENGMTPLMHAAYKGKLDMCKLLLRHGAD 71

  Fly    73 INLNQHGADYTPLHFAALSGNTHVCRLLLDAGIKPGSINSVNRTAAQMAAFVGNHACVETINNYV 137
            :|.:||...||.|.|||||||..:..::|:||.:...:|||.|||||||||||.|.||..|||:.
Human    72 VNCHQHEHGYTALMFAALSGNKDITWVMLEAGAETDVVNSVGRTAAQMAAFVGQHDCVTIINNFF 136

  Fly   138 TQSSLEYYTQVHGQQTEPHIPPSLLKSFHAFVTEINLHPVRIALNVQSLGLLRILSSLRK---TL 199
            .:..|:|||:..|...||.:||.|....|..:|..|||||:|.:.|....||...::|.|   .:
Human   137 PRERLDYYTKPQGLDKEPKLPPKLAGPLHKIITTTNLHPVKIVMLVNENPLLTEEAALNKCYRVM 201

  Fly   200 ALMCEKEMQKSHDLNELLAFKFHYQGWILAELIRCEEQFKAQHKEKSGEEAGDANKNDFIEMFVK 264
            .|:|||.| |..|:||:||.|.||        |.|..| |..:..|.||     ||   ::..:|
Human   202 DLICEKCM-KQRDMNEVLAMKMHY--------ISCIFQ-KCINFLKDGE-----NK---LDTLIK 248

  Fly   265 RVLKENKLGQLD-----YVEYTLRECAREFPVRECTIFRQIATQFGAKDA---PPALTVLRNAIN 321
            .:||    |:..     |.|..:||..|:||..|.|:.:|:.......:.   |.|.:||..||.
Human   249 SLLK----GRASDGFPVYQEKIIRESIRKFPYCEATLLQQLVRSIAPVEIGSDPTAFSVLTQAIT 309

  Fly   322 GMRWITDEGNYCSTCGAEKPDKKCSKCKAVQYCDRECQRLHWFMHKKNCARLL----AQSQAQAQ 382
            |.....|. .:|:|||.:...|:||.||.|.|||:.||:.|||.|||.|..|.    .|....|:
Human   310 GQVGFVDV-EFCTTCGEKGASKRCSVCKMVIYCDQTCQKTHWFTHKKICKNLKDIYEKQQLEAAK 373

  Fly   383 AQPQSQAKGAID 394
            .:.|.:..|.:|
Human   374 EKRQEENHGKLD 385

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8003	NP_001261683.1	ANK	21..133	CDD:238125	55/113 (49%)
		Ank_2	21..107	CDD:289560	38/87 (44%)
		ANK repeat	46..76	CDD:293786	14/29 (48%)
		ANK repeat	78..105	CDD:293786	13/26 (50%)
		zf-MYND	333..370	CDD:280009	21/36 (58%)
ANKMY2	NP_064715.1	ANK repeat	16..43	CDD:293786	10/27 (37%)
		Ank_2	<30..>236	CDD:330894	98/216 (45%)
		ANK	31..132	CDD:238125	54/101 (53%)
		ANK repeat	45..77	CDD:293786	14/31 (45%)
		ANK 1	45..74		13/28 (46%)
		ANK repeat	79..110	CDD:293786	13/30 (43%)
		ANK 2	79..108		13/28 (46%)
		ANK 3	159..188		10/28 (36%)
		zf-MYND	320..357	CDD:307734	21/36 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	374..441		3/12 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165153150
Domainoid	1	1.000	124	1.000	Domainoid score	I5559
eggNOG	1	0.900	-	-		E2759_KOG1710
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10662
Inparanoid	1	1.050	242	1.000	Inparanoid score	I3337
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG49449
OrthoDB	1	1.010	-	-		D1413951at2759
OrthoFinder	1	1.000	-	-		FOG0006328
OrthoInspector	1	1.000	-	-		oto91836
orthoMCL	1	0.900	-	-		OOG6_107373
Panther	1	1.100	-	-	LDO	PTHR24150
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2471
SonicParanoid	1	1.000	-	-		X4604
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.800