DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG8003 and INVS

DIOPT Version :9

Sequence 1:NP_001261683.1 Gene:CG8003 / 39210 FlyBaseID:FBgn0036096 Length:407 Species:Drosophila melanogaster
Sequence 2:NP_055240.2 Gene:INVS / 27130 HGNCID:17870 Length:1065 Species:Homo sapiens


Alignment Length:280 Identity:66/280 - (23%)
Similarity:113/280 - (40%) Gaps:48/280 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly    12 DDVQRQLLD------------------HLA--KNDTSGFKQLLSGVRNVNFVDDTGMSCLAHASF 56
            |||.|.:|.                  |.|  ....|..|.||.....|:..|....:.|..|..
Human   335 DDVLRTMLSLKSDIDINMADKYGGTALHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACE 399

  Fly    57 KGNREAVQLLLDMGADINL-NQHGADYTPLHFAALSGNTHVCRLLLDAGIKPGSINSVNRTAAQM 120
            .|:::.:|.|:..||.::| :|.|  ::.||:|||.||..||::|::..|.|...:...||..|.
Human   400 MGHKDVIQTLIKGGARVDLVDQDG--HSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQC 462

  Fly   121 AAFVGNHACVETINNYVTQSSL---EYYTQVHGQQTEPHIPP-SLLKSFHAFVTEINLH-----P 176
            ||:.|...|:..:.......::   |..|.:|......::.. .||..|.||..::..:     |
Human   463 AAYGGYINCMAVLMENNADPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTP 527

  Fly   177 VRIALNVQSLGLLRILSSLRKTLALMCEKEMQKSHDLNELLAFKFH--YQGWILAELIRCEEQFK 239
            :..||          |....:.:..|.|........:.::.|||..  |:|:.:.:..|..:...
Human   528 LDYAL----------LGERHEVIQFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLL 582

  Fly   240 AQH----KEKSGEEAGDANK 255
            .:|    |:.:.::..:.||
Human   583 MKHEQLRKDAAAKKREEENK 602

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG8003NP_001261683.1 ANK 21..133 CDD:238125 37/114 (32%)
Ank_2 21..107 CDD:289560 29/88 (33%)
ANK repeat 46..76 CDD:293786 8/30 (27%)
ANK repeat 78..105 CDD:293786 11/26 (42%)
zf-MYND 333..370 CDD:280009
INVSNP_055240.2 ANK 1 13..42
Ank_2 19..111 CDD:289560
ANK 42..169 CDD:238125
ANK repeat 47..78 CDD:293786
ANK 2 47..76
ANK repeat 80..146 CDD:293786
ANK 3 80..110
Ank_2 85..179 CDD:289560
ANK 4 113..144
ANK 143..309 CDD:238125
ANK repeat 148..179 CDD:293786
ANK 5 148..177
ANK repeat 181..218 CDD:293786
ANK 6 181..213
Ank_4 185..240 CDD:290365
ANK repeat 220..252 CDD:293786
ANK 7 220..250
Ank_2 225..319 CDD:289560
ANK 8 254..283
ANK repeat 256..286 CDD:293786
ANK 9 288..317
ANK repeat 288..313 CDD:293786
Ank_2 293..387 CDD:289560 12/51 (24%)
ANK 316..443 CDD:238125 32/109 (29%)
ANK repeat 321..354 CDD:293786 5/18 (28%)
ANK 10 321..350 5/14 (36%)
ANK repeat 356..387 CDD:293786 7/30 (23%)
ANK 11 356..385 7/28 (25%)
Ank_2 361..453 CDD:289560 30/93 (32%)
ANK 384..509 CDD:238125 34/126 (27%)
ANK repeat 389..420 CDD:293786 8/30 (27%)
ANK 12 389..418 7/28 (25%)
ANK repeat 422..453 CDD:293786 13/32 (41%)
ANK 13 422..451 13/30 (43%)
Ank_2 427..517 CDD:289560 27/89 (30%)
ANK repeat 455..486 CDD:293786 7/30 (23%)
ANK 14 455..484 7/28 (25%)
ANK 15 488..517 8/28 (29%)
ANK repeat 488..516 CDD:293786 8/27 (30%)
D-box 1 490..498 2/7 (29%)
ANK repeat 521..548 CDD:293786 6/36 (17%)
ANK 16 523..553 6/39 (15%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 589..833 3/14 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 847..886
D-box 2 909..917
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 976..999
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 1 0.950 - 0 Normalized mean entropy S4213
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.860

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