DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8003 and ankmy2

DIOPT Version :9

Sequence 1:	NP_001261683.1	Gene:	CG8003 / 39210	FlyBaseID:	FBgn0036096	Length:	407	Species:	Drosophila melanogaster
Sequence 2:	XP_031759665.1	Gene:	ankmy2 / 100495680	XenbaseID:	XB-GENE-940733	Length:	454	Species:	Xenopus tropicalis

Alignment Length:	409	Identity:	152/409 - (37%)
Similarity:	221/409 - (54%)	Gaps:	47/409 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 QLDDVQRQLLDHLAKNDTSGFKQLLSG--VRNVNFVDDTGMSCLAHASFKGNREAVQLLLDMGAD 72
            :|.:.:||||.|:::.:....::||..  || ||.:|:.||:.|.||::||..:..:|||..|||
Frog     7 ELTEEERQLLTHISQGNIQETRRLLGSKDVR-VNCLDEHGMTPLMHAAYKGKVDMCKLLLQHGAD 70

  Fly    73 INLNQHGADYTPLHFAALSGNTHVCRLLLDAGIKPGSINSVNRTAAQMAAFVGNHACVETINNYV 137
            :|.|:|...||.|.||.||||..:..|:|:||.....:|||.|||||||||||.|.||..|||:.
Frog    71 VNCNEHEHGYTALMFAGLSGNKEIAWLMLEAGADADVVNSVGRTAAQMAAFVGQHDCVTVINNFF 135

  Fly   138 TQSSLEYYTQVHGQQTEPHIPPSLLKSFHAFVTEINLHPVRIALNVQSLGLLRILSSLRK---TL 199
            .:..|:|||:..|...||.:|..|....:..:|..|||||:|...::...||..:.:|:|   .|
Frog   136 PREKLDYYTKTQGLNKEPKLPSKLAGPLYKVITTTNLHPVKIVFLIKENPLLMEIDALKKCCTVL 200

  Fly   200 ALMCEKEMQKSHDLNELLAFKFHYQGWILAELIRCEEQFKAQHKEKSGEEAGDANKNDFIEMFVK 264
            .|:|||.| |..|:||:||.|.||   |...:.:|....:.|              .|.::.|:|
Frog   201 DLICEKCM-KQKDMNEVLAVKMHY---ISCVMQKCSTFLQDQ--------------EDKLDNFIK 247

  Fly   265 RVLKENKLGQLD------YVEYTLRECAREFPVRECTIFRQIATQFGAKDA---PPALTVLRNAI 320
            .:||..     |      :.|..:|||.|:||..|.|:.:|:.......:.   |.|.::|..||
Frog   248 NLLKGR-----DPDCFPVFQEKFIRECIRKFPYCEATLLQQLVRSIAPVEIGSDPTAFSILTQAI 307

  Fly   321 NGMRWITDEGNYCSTCGAEKPDKKCSKCKAVQYCDRECQRLHWFMHKKNCARLLAQSQAQAQAQP 385
            .|.....| .::|:|||.:...|:||.||.|.|||:.||:||||.|||.|..|..:.:.|.:...
Frog   308 TGQVGFID-ADFCTTCGEKGATKRCSVCKLVIYCDQNCQKLHWFTHKKVCKMLKEKREKQEEEAA 371

  Fly   386 QSQAKGAIDTAELREELSK 404
            :.:.:        :|:|||
Frog   372 REKRR--------QEKLSK 382

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8003	NP_001261683.1	ANK	21..133	CDD:238125	54/113 (48%)
		Ank_2	21..107	CDD:289560	37/87 (43%)
		ANK repeat	46..76	CDD:293786	14/29 (48%)
		ANK repeat	78..105	CDD:293786	13/26 (50%)
		zf-MYND	333..370	CDD:280009	22/36 (61%)
ankmy2	XP_031759665.1	Ank_2	19..109	CDD:403870	36/90 (40%)
		ANK repeat	44..75	CDD:293786	14/30 (47%)
		ANK repeat	78..109	CDD:293786	13/30 (43%)
		Ank_2	83..>144	CDD:403870	33/60 (55%)
		zf-MYND	319..356	CDD:396356	22/36 (61%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	123	1.000	Domainoid score	I5561
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10662
Inparanoid	1	1.050	249	1.000	Inparanoid score	I3161
OMA	1	1.010	-	-		QHG49449
OrthoDB	1	1.010	-	-		D1413951at2759
OrthoFinder	1	1.000	-	-		FOG0006328
OrthoInspector	1	1.000	-	-		oto105591
Panther	1	1.100	-	-	LDO	PTHR24150
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2471
SonicParanoid	1	1.000	-	-		X4604
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110